Y. Tian

This paper uses cryo-electron tomography to visualize how different Aβ assembly forms interact with lipid membranes, revealing that oligomers and protofibrils disrupt membrane integrity while monomers and fibrils have minimal impact.

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

This study shows that BCP and Pre-C mutations in HBV increase viral replication but reduce immune tolerance, with Pre-C mutations causing more severe immune responses and shorter viral persistence in mice.

The paper identifies ACE2 and IL-6 as non-canonical interferon-stimulated genes with epigenetic features linked to COVID-19 susceptibility across vertebrates.

This study uses a 3D air-liquid interface culture model to show that nasopharyngeal epithelial cells can be infected by EBV, with single-cell RNA-sequencing identifying distinct EBV transcription profiles.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

This study investigates the micro- and macroevolution of Prevotella copri-containing lineage in primate guts, revealing co-evolution with humans, host jumping, and horizontal gene transfer.

This study optimizes metagenomic sequencing for diagnosing central nervous system infections by establishing detection thresholds and reducing false positives through computational filters and controls.

This study shows that S100A9 promotes neural stem cell differentiation and inhibits their stemness, suggesting a role in neurodegenerative disease progression.

This study shows that miR-203 suppresses pancreatic cancer cell proliferation, invasion, and migration by down-regulating FGF2 expression.

This study investigates the conformational states of full-length Bcl-xL in soluble and membrane-anchored forms using NMR, MD simulations, and ITC to understand its structure and ligand binding.

The paper introduces DPSN, a database that standardizes short names of amplicon-sequencing primers to reduce ambiguity and improve communication.

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.

This paper identifies and characterizes 359 RXLR effectors in nine Pythium species, revealing evolutionary patterns and functional roles in host interactions.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

This study identifies LncRNA MIR4435-2HG as a mediator of cisplatin resistance in HCT116 cells via the Nrf2/HO-1 pathway.

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

The paper uses scRNA-seq to show that single cells from the same donor can express different HLA class I genotypes, revealing high allele-specific expression diversity in the immune system.

The paper introduces eFLASH, a method for rapid, uniform labeling of organ-scale tissues, enabling scalable proteomic phenotyping across species and tissues.

The paper describes a modified Helios mass cytometer protocol that improves data quality and reduces inter-instrument variability in multi-center studies.

This study shows that knocking down DGKZ in HL-60 cells induces apoptosis and G2/M phase arrest via the caspases pathway.

This study shows that vitamin A supplementation after neonatal Streptococcus pneumoniae pneumonia reduces allergic asthma in mice by altering CD4+ T cell subsets.

The study examines EGFR exon19 mutation subtypes in non-small cell lung adenocarcinoma and finds that CSS mutations are associated with shorter progression-free survival compared to CD/CSS+SNV mutations.

This study evaluates the sublethal effects of SYP-9625 on Tetranychus cinnabarinus and its impact on the predatory mite Neoseiulus californicus, showing reduced pest population growth and minimal effect on the predator.

This study shows Tolloid cleavage activates latent GDF8 by destabilizing prodomain-growth factor interfaces and priming the growth factor for release.