Y. Yang

The paper identifies SLK splicing dysregulation in cancers, showing SLK-L promotes metastasis while SLK-S inhibits it, with Rbfox2 regulating this splicing event.

This study demonstrates that TRPV1-mediated sonogenetics can safely modulate motor cortex activity in mice, inducing behavioral changes without significant tissue damage.

The paper examines chromosome number evolution in sundew plants, finding higher rates of single chromosome gain and loss in one subgenus compared to others, with no support for holocentromere or diploidization explanations.

This study identifies the C-terminal domains of RNase H and integrase as regulators of virus release and autoprocessing in a defective HIV-1 variant with specific mutations.

This study develops an electromagnetic stretching device to apply controlled mechanical strain to endothelial cells, revealing strain-dependent cellular and nuclear orientation and the effects of overstretching on endothelial function.

This study investigates the evolutionary mechanisms behind the loss of anthocyanin pigmentation in betalain-pigmented Caryophyllales by analyzing gene expression and duplication patterns in flavonoid pathway genes.

This study identifies IL24 as a tissue repair pathway parallel to IFN-mediated host defense, showing its role in epithelial and mesenchymal regeneration after injury.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

The paper identifies a cysteine-rich pattern recognized by plant receptors from three microbial kingdoms, showing convergent evolution of immune responses.

The paper shows that wildflower phenological sensitivity to spring temperature is conserved across continents, but canopy trees in North America are more temperature-sensitive than in Asia and Europe.

This study identifies the origin of genetic risk variants for multiple sclerosis in Steppe pastoralist populations and traces their spread into Europe through migration.

This paper demonstrates a method to efficiently conjugate biomacromolecules to antibodies using modified Fc glycan and an engineered enzyme, enabling rapid and homogeneous antibody conjugates with therapeutic applications.

The study identifies CsFLC1 in tea plants, showing it influences flowering and bud dormancy, and demonstrates its function in Arabidopsis by promoting early flowering and affecting gene expression related to flowering and hormone pathways.

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

The paper investigates SULF1 and SULF2 in HNSC and other cancers, finding SULF1 is secreted by fibroblasts and negatively impacts survival early, while SULF2, from tumor cells, affects survival later, with implications for therapy.

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

This study investigates the effects of cell-free fat extract (CEFFE) on osteoclastogenesis, showing its ability to reduce bone loss and inhibit osteoclast formation through antioxidant and calcium signaling modulation.

The paper identifies 4 immunoprognostic genes in ccRCC using bioinformatics analysis of public databases and validates their association with prognosis and immunotherapy response.

This study identifies aCcr1, an archaeal transcription factor, and its viral homologs as regulators of cell cycle progression, showing they control cell division by repressing cdvA expression.

This paper reports the genome assembly of Vaccinium darrowii, identifies adaptation traits, and delineates cuticle biosynthesis pathways to aid blueberry breeding.

The paper reports the first crystal structure of a coronavirus M protein from batCOV5 and identifies its interaction with the N protein.

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

This study investigates the evolution of the CtBP transcriptional corepressor, showing its bilaterian origin, conserved CTD structure, and lineage-specific variations through alternative splicing and gene duplication.

This study uses deep learning to predict neoadjuvant chemotherapy benefit in breast cancer using stromal histology, introducing the TS-score which outperforms existing predictors.

The paper identifies anthracyclines as HIF-1 inhibitors that reduce tumor vascularization by blocking HIF-1 target genes and angiogenesis.

This study identifies NSUN2-mediated m5C modification as a regulator of hepatocellular carcinoma progression through oncogene expression and Ras signaling pathway modulation.

This paper identifies AtD27-like1 as a cis/cis-{beta}-carotene isomerase that contributes to strigolactone biosynthesis and negatively affects ABA levels in Arabidopsis.