Y. Yang

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

This study investigates how Puerarin affects osteoclast proliferation and function through the PI3K-AKT signaling pathway, showing it reduces osteoclast activity by modulating antioxidant-related proteins.

This study determines the crystal structure of ABCG5/G8 in a cholesterol-bound state and identifies a conserved phenylalanine array that supports sterol selectivity.

The paper identifies two regulatory modes in the Arabidopsis CHS3/CSA1 immune receptor pair, showing how an integrated domain (ID) in clade 1 CHS3 enables effector binding, while other clades rely on detecting effector-modified pattern recognition receptors.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

This study investigates how PVSRIPO virotherapy activates microglia and myeloid cells in gliomas, leading to antitumor inflammation and improved outcomes when combined with PD1/PD-L1 blockade.

This paper develops shell microelectrode arrays (MEAs) for brain organoids, enabling long-term electrophysiology recording from 3D organoids.

This study profiles size-dependent membrane protein heterogeneity in small EVs to improve cancer diagnosis accuracy using a novel single EV enumeration approach.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

The paper improves an anti-malarial antibody using an in silico pipeline, resulting in a variant with higher binding affinity and better malaria protection.

This study identifies novel antibody interfaces through structural analysis, revealing recurrent motifs and enabling their functional validation and optimization.

This paper uses network mapping to identify plant genes and SNPs that influence microbial network architecture in Arabidopsis thaliana, revealing genetic control of microbial interactions and their impact on plant traits.

This study investigates calcium-independent ER-PM contact site oscillations in RBL mast cells and their role in SOCE, showing PI(4)P dependency and the importance of reversible contact sites for calcium oscillations.

This study identifies m6A modification patterns and functions during sexual reproduction in Chlamydomonas reinhardtii, showing its role in regulating microtubule-based processes.

This study shows that adaptive immune cells around biomaterials promote hair follicle regeneration by activating fibroblasts, highlighting their role in wound healing.

This paper shows that childhood vaccines can enhance antitumor immunity by coordinating CD4+ T cells, CD8+ T cells, and eosinophils in mouse models and correlates these effects with human transcriptome data.

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

This study shows that alveolar regeneration after viral infection occurs independently of tuft cells, with ectopic basal progenitor cells generating alveolar epithelial cells through distinct differentiation paths.

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

The paper uses time-lapse imaging to study EMT in human cells, revealing two distinct transition paths through a multidimensional feature space.

This study shows that colistin resistance in E. coli increases resistance to host antimicrobial peptides and virulence, highlighting risks of therapeutic AMP use.

This study shows that heparan sulfate-dependent RAGE oligomerization is essential for RAGE signaling and demonstrates a monoclonal antibody that blocks this interaction.

This study identifies ORANGE family proteins as regulators of chlorophyll and carotenoid biosynthesis in plants, showing their role in coordinating these pathways for photosynthesis and thermotolerance.

The paper introduces a database of non-covalent interactions in protein-ligand complexes using experimental electron density data and demonstrates its application in studying amide-pi interactions.

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.