Z. Yang

This study maps the dynamic trajectories of intracellular gene transfers in Poaceae using a novel tool, revealing lineage-specific patterns and functional roles of nuclear organelle genes.

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

This study identifies YTHDF1 as an oncogenic m6A reader promoting AML by enhancing oncogenic translation and shows tegaserod inhibits its function.

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

This study shows that CD4bs immunogens can elicit potent, broad anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals.

This study examines immune dynamics at the protein level in vaccinated individuals infected with delta or omicron variants, finding reduced NK cells and increased T and B cells, and that booster doses reduce infection severity.

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

This paper characterizes monoclonal antibodies that recognize the CD4-induced open conformation of HIV-1 Env trimers and describes their structural interactions with Env and CD4.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

The paper shows SERINC3 has a structure similar to lipid transporters and demonstrates its lipid flipping activity, which correlates with reduced HIV-1 infectivity.

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

The paper identifies BCR ligation as a mechanism for eliminating IgE plasma cells, showing it induces apoptosis and is regulated by Syk, BLNK, and PLCγ2.

This paper introduces a new fluorescent marker, PKMO, enabling 3D live-cell STED nanoscopy of mitochondria with improved photostability and reduced phototoxicity, allowing multiplexed imaging of mitochondrial dynamics and interactions.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

HSP90.6 regulates maize grain filling by affecting 26S proteasome-mediated nitrogen recycling and GF14-6-mediated carbon metabolism.

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

This paper develops a ferritin-based nanoparticle vaccine targeting the SARS-CoV-2 Omicron variant, showing enhanced immunogenicity compared to a non-nanoparticle version.

This study shows that seasonality, not photoperiodism, affects the susceptibility of spider mites to pesticides, with toxicity increasing in spring and summer and decreasing in winter.

This study identifies two antibodies from immunized macaques that neutralize HIV-1 by targeting the CD4-binding site on an occluded-open Env trimer conformation.

This study shows that multigenerational high-fat diet feeding in mice leads to improved metabolic health through microbiome adaptation, with leaner mice passing on resistance to obesity.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

This study investigates how salt stress affects oil palm by analyzing gene expression and stomatal development, finding that EgSPCH promotes stomatal increase which aids in salt tolerance.

The paper reanalyzes genomic data from North American chipmunks to detect cross-species gene flow using a full likelihood method, finding robust evidence for ancient nuclear introgression.

This paper identifies PsFYVE1, a novel effector from Phytophthora sojae, which modulates plant immunity by altering transcription and alternative splicing of immunity-related genes through interaction with host RNA-binding proteins.

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This paper introduces a ratiometric multi-color imaging strategy for 4Pi-SMLM that achieves optimal 3D resolution and color separation with minimal loss of localization precision.

This study identifies vaccinia virus D10 as a mitochondria-localized decapping enzyme that promotes viral replication by preferentially targeting cellular mRNAs for decapping and enhancing viral mRNA translation.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.