C. Lin

This study identifies that FisB catalyzes bacterial membrane fission through homo-oligomerization and lipid-binding, without requiring curvature sensing or lipid microdomains.

The paper introduces DNA-origami-based fluorescence brightness standards for fast and convenient protein counting in live cells, compatible with various imaging applications.

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

This study shows miR-224 promotes HCC cell migration and invasion by targeting HOXA5 and ADAM17, suggesting it as a potential therapeutic target.

This study identifies two new QTLs, Scon3 and Scon4, that influence sucrose intake in mice and act through a common postoral mechanism.

This study identifies QTLs for sucrose consumption and neural responses in mice, finding new loci and confirming a known one involving the Tas1r3 gene.

This study uses DNA-origami NPC mimics to show HIV-1 capsid uses a trimeric interface and RRR motif to pass through nuclear pores, bypassing the FG motif of NUP153.

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.

This study identifies calcitriol, the active form of vitamin D, as a potent inhibitor of SARS-CoV-2, suggesting its potential as a prophylactic agent against COVID-19.

The paper reports the crystal structure of SARS-CoV-2 main protease bound to shikonin, revealing conformational changes and binding modes that could inform drug design.

This study shows that inhibiting CAMKK2 blocks autophagy and slows castration-resistant prostate cancer by disrupting AMPK-ULK1 signaling.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

This paper introduces a fluorogenic DNA-PAINT probe that reduces background and increases imaging speed for 3D whole-cell DNA-PAINT.

This study shows chronic IL-1 exposure leads to androgen and AR independence in LNCaP prostate cancer cells, promoting castration-resistant prostate cancer development.

This paper presents a microfluidic ELISA technology for rapid, quantitative, and sensitive detection of SARS-CoV-2 biomarkers in small sample volumes.

This paper introduces a DNA-brick assisted centrifugation method to sort liposomes by size, enabling the study of membrane curvature effects on protein activity.

This study shows CpG-ODN 2007 reduces mortality and toxicity in zebrafish infected with Vibrio vulnificus and modulates immune gene expression.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study identifies PeGATA transcription factors in moso bamboo and shows they regulate shoot growth and rhizome development via GA signaling pathway.

This paper introduces a fast MRSI technique for musculoskeletal fat quantification, producing separate lipid component maps with improved sensitivity compared to standard Dixon methods.

This study uses smFRET to show circovirus capsid undergoes reversible conformational changes, regulated by heparan sulfate and neutralizing antibodies, revealing dynamics in receptor binding.

This study uses full-length transcriptome sequencing to analyze salt tolerance mechanisms in Spartina alterniflora and identifies key genes and regulatory networks involved in stress response.

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

This study evaluates the impact of China's Public Health Service Equalization Program on hypertension control using survey data, finding improved control rates and regional variability linked to administrative systems.

This study uses DNA-origami structures to measure lipid transfer distances mediated by the SMP domain of E-Syt1, supporting a shuttle model over a distance exceeding the SMP dimer length.

The paper uses AFM to study biomolecular dynamics in real and synthetic nuclear pore complexes, revealing slow collective transitions in mimetic NPCs due to FG-nup interactions.

This study shows that high IQGAP3 expression in breast cancer is linked to poor prognosis and resistance to radiation therapy.

This study shows autophagy promotes osimertinib resistance in EGFR-mutant lung cancer by enhancing stem-cell like properties, and inhibiting autophagy reverses resistance.

The paper introduces a GPU-accelerated implementation of thermodynamic integration in AMBER for faster and more efficient alchemical free energy calculations.