C. Liu

This study identifies a unique CD8+ T cell population in AD mouse brains that contributes to amyloid beta-associated memory loss and shows that reducing these cells improves memory and reduces plaque formation.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

This paper develops a vascularized bile duct-on-a-chip model to study PSC, showing PSC cholangiocytes exhibit increased inflammation under IL-17A stimulation.

This study identifies PIF4 as a key regulator of water use efficiency under fluctuating light and drought in rice by modulating SAL1 and NHX1 gene expression.

This study identifies Fkbp5 as a regulator of epithelial cell quiescence-proliferation transition via Akt signaling in zebrafish using transcriptomics and genetic approaches.

The paper identifies a conserved pressure-driven mechanism for osmoregulation using contractile vacuoles in three distantly related eukaryotic species.

This study shows that HERG channels in intestinal L-cells regulate GLP-1 secretion by modulating action potential duration and intracellular calcium.

This paper introduces a self-healing PDMS material with safety-enhancing properties for wireless, skin-interfaced bioelectronic devices.

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

This study shows TRAF4 is essential for ST2+ memory Th2 cell proliferation in IL-33-driven type 2 airway inflammation, revealing its role in AKT/mTOR and ERK1/2 signaling and gene expression.

This study shows that extracellular vesicles from obese women's breast adipose tissue promote mitochondrial metabolism and proliferation in ER+ breast cancer cells.

This study shows that cardiac fibroblasts protect cardiomyocytes from ferroptosis and regulate fibrosis after myocardial injury through paracrine factors and Pitx2 signaling.

This study shows that Arh2 deficiency leads to cardiac dysfunction, tumorigenesis, inflammation, and reduced survival in mice.

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

This paper introduces TSD, a Transformer-based model for seizure detection in EEG signals, achieving 92.1% AUROC on the TUH dataset.

This study identifies AeHGO, a CAD-like enzyme, as the branch point enzyme in the shikonin biosynthetic pathway of A. euchroma, showing it catalyzes reversible oxidation/reduction of key intermediates.

The paper investigates how dalpiciclib affects ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer and identifies CALML5 as a risk factor.

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

PACESS analyzes 3D bone marrow images to study spatial interactions between cell types, revealing new microenvironments influenced by leukemic cell clusters.

This study identifies a mitochondrial signaling loop involving Sgk1 that regulates epithelial cell plasticity in zebrafish and human cancer cells.

This study investigates the fetal response to injury in extrahepatic bile ducts (EHBDs) and identifies a fetal wound healing program characterized by high molecular weight HA, which may lead to obstruction in biliary atresia.

This study identifies HAO2 as a regulator of fatty acid metabolism in CKD rat kidneys, showing its reduced expression and role in lipid accumulation and metabolic dysfunction.

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

The paper identifies distinct super-enhancer elements that differentially regulate Il2ra expression in DN2/DN3 thymocytes and Treg cells versus mature T and NK cells.

This study examines the prevalence and risk factors of HIV-1 associated thrombocytopenia and its link to neuroinflammation in a hospital in western China.