C. Wu

This study investigates the molecular evolution of protein sequences and codon usage in monkeypox viruses, identifying positive selection, accelerated evolution, and codon deoptimization patterns.

This study shows that PP4 inhibition enhances ovarian cancer sensitivity to NK cell-mediated cytotoxicity through STAT1 activation and inflammatory signaling.

This study shows that hematopoietic stem cells continuously replenish tissue-resident macrophages in healthy adult macaques, challenging the notion that all macrophages are derived from yolk sac cells.

This study shows chemotherapy-induced reactive myelopoiesis and FX-expressing macrophages promote cancer lung metastasis through CCL2/CCR2 axis and coagulation-inflammation interplay.

This paper develops engineered retrovirus-like nanocarriers for efficient mRNA delivery into neurons by modifying extracellular vesicles with Arc protein capsids and RNA elements.

This study investigates how DNA mismatches affect nucleosome mechanical stability and DNA exposure using single-molecule techniques, finding that C-C mismatches increase stability and reduce accessibility.

This study compares neutralizing antibody titers after monovalent and bivalent mRNA boosters against SARS-CoV-2, finding comparable levels against BA.5.

This study shows that Mediator kinase inhibition prevents resistance to ERK/MAPK inhibitors in KRAS-mutant cancers by blocking transcriptional plasticity.

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.

This study shows that DNA damage-induced O-GlcNAcylation of YTHDC1 enhances its m6A binding, promoting homologous recombination and genome stability.

This study identifies EFNA4 amplification as a driver of lung adenocarcinoma lymph node metastasis through genomic analysis and functional experiments.

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

This study identifies Abl2's role in microtubule nucleation and repair through tubulin co-condensation and direct interactions.

The paper screens a botanical extract library against Staphylococcus aureus and identifies a sesquiterpene lactone from Liriodendron tulipifera with inhibitory activity against methicillin-susceptible strains.

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

This study quantifies neoantigen-mediated immunoediting stages in cancer evolution across tumor types, showing elimination and escape signals predict immunotherapy response.

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

This study identifies tRNA thiolation as essential for plant immunity by showing its role in regulating NPR1 translation and salicylic acid signaling in Arabidopsis.

This paper introduces a mouse model of rectal cancer that mimics human tumor progression and radiation response for preclinical studies.

This study evaluates vaccine efficacy against SARS-CoV-2 Omicron in macaques, finding that both humoral and cellular immune responses are necessary for virologic control.

This study shows that extrachromosomal DNA (ecDNA) is linked to reduced immune cell infiltration and antigen presentation, suggesting it helps cancer cells evade immune surveillance.

This study shows ATP binding enables SWR1 chromatin remodeler to diffuse along DNA, facilitating efficient target search by sliding over DNA until encountering roadblocks.

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

This study identifies how viral RNA interacts with coat proteins to sense host environments and trigger capsid disassembly in Turnip crinkle virus.

This study shows Ste50p localizes to polarity sites during yeast shmoo formation and correlates with cell-fate decisions in response to pheromone.

The paper uses single-molecule FRET to show SWR1 unwraps DNA and exchanges H2A-H2B for H2A.Z-H2B with timed precision.

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

This study investigates HMGB1's role in invasive C. albicans infection and shows that EP reduces HMGB1 levels, tissue damage, and mortality in infected mice.