C. Wu

This study identifies SiCEP3, a C-terminally encoded peptide from Setaria italica, which promotes ABA import and signaling by inhibiting receptor kinase activity under abiotic stress.

The paper identifies distinct neural circuits regulating AVP neuron activity during drinking and eating, revealing presystemic regulation mechanisms for osmolality anticipation.

This paper constructs and analyzes metabolic models of Drosophila gut microbiota under different nutrient regimes to reveal dynamic metabolic interactions and their impact on host physiology.

This study characterizes the SARS-CoV-2 N protein, identifying domain-specific functions and highlighting the C-terminal domain's immunogenicity for diagnostic applications.

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

The paper evaluates methods to enhance skin permeation of decapeptide-12, finding that microneedle patches with palmitate-modified peptides provide the best delivery.

This study maps host-parasite-microbiome interactions in Chagas disease, identifying metabolic factors that influence tissue tropism and disease tolerance.

This paper develops a semi-supervised deep learning model for colorectal cancer recognition using pathological images, showing it outperforms supervised learning with limited labeled data and matches pathologists' performance.

The paper analyzes proteome and phosphoproteome changes in EGFR TKI-resistant lung cancer cells to identify drug targets that can overcome resistance.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This study identifies integrin activation and apoptosis as the mechanism of rapid platelet clearance after cold storage and shows that EGTA treatment enables cold storage of platelets for transfusion.

The paper shows extracellular histones cause disseminated intravascular coagulation (DIC) via tissue factor-dependent lytic cell death, independent of inflammasome or TLR pathways.

This study shows that culturing murine BMSCs under hypoxia reduces hematopoietic contamination and increases stromal cell population.

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

The paper quantifies vertebrate biodiversity in Ailaoshan reserve using leech iDNA, showing species richness increases with elevation and distance from the reserve edge.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

This study shows that replacing amino acids 11 and 12 in mouse angiotensinogen with human counterparts does not affect renin cleavage or angiotensin II-mediated functions in mice.

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

This study shows LIMD1 phase separation at focal adhesions regulates force sensing and durotaxis by controlling FA dynamics in response to mechanical cues.

This paper shows that increasing cryo-EM sample freezing temperature reduces beam-induced motion and improves reconstruction resolution by including more undamaged initial frames.

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

This study identifies novel glycerolated quinazolinones produced by Streptomyces sp. MBT27 under glycerol-induced conditions and elucidates their biosynthetic pathway.

This study identifies Lsm12 as a regulator that mediates Polη deubiquitination to enhance its recruitment and improve survival under oxidative stress in yeast.

The paper identifies the SUMO-Ubiquitin-Cdc48 pathway as a negative regulator of RNA polymerase III in budding yeast, leading to proteasomal degradation of Pol III subunits and repression of transcription.

This study shows that angular compounding in optical coherence tomography reduces speckle but with limited signal-to-noise ratio improvement due to optical aberrations and resolution trade-offs.