D. Liu

The paper identifies MIK2 as a plant receptor that recognizes conserved peptide motifs from phytocytokines and microbial proteins, triggering immune responses through a signaling relay.

This study identifies rosmarinic acid as a potent inhibitor of amylin aggregation and shows its efficacy in reducing amyloid deposits and mitigating diabetic pathology in HIP rats.

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.

The paper develops a method to trace the geographic origin of quarantine insects using their gut microbiota, finding that microbiota diversity and composition correlate with geographic and environmental factors.

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

This study compares gene expression in oil pathways between yellow and purple nutsedge to identify factors contributing to high oil accumulation in yellow nutsedge tubers.

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

This paper introduces MOAlmanac, a clinical interpretation algorithm that integrates genomic and transcriptional data to improve precision cancer treatment decisions by considering second-order molecular features.

The paper investigates fungal and yeast communities in spontaneous wine fermentations, finding geographic differentiation and S. cerevisiae's role in shaping wine aroma profiles.

This study identifies the ERK2-p53 complex as a therapeutic target in KRAS-mutant stomach/colorectal cancers, showing that disrupting it with MEK1/2 and ERK2 inhibitors induces apoptosis.

This paper develops CR3022-CAR-NK cells to target SARS-CoV-2, showing they can bind viral proteins and kill infected cells in vitro.

This study shows PKD1 phosphorylates CBX8, disrupting PRC1 complex binding and promoting cell senescence by derepressing p16.

The paper analyzes SARS-CoV-2 genome sequences to study mutation patterns and evolutionary dynamics, identifying mutations that may enhance viral fitness and provide insights for vaccine development.

This study characterizes the subcellular localization of SARS-CoV-2 proteins using expression in human cells and immunofluorescent assays, revealing their association with various organelles.

The paper identifies new integrin antibodies that inhibit fibrosis progression in lung injury models and show superior in vitro activity in fibroblasts.

The paper uses proteomic approaches to identify proteins modified during excitotoxic neuronal death and shows that blocking Src kinase protects neurons in a rat model.

This paper develops a rapid, sensitive, and low-cost nanozyme-based chemiluminescence paper test for SARS-CoV-2 antigen detection with results in under 16 minutes.

The paper identifies PRMT5 as a synthetic lethal target with gemcitabine in pancreatic cancer using CRISPR screening in a PDX model.

This study identifies non-canonical proline-tyrosine interactions in the Ebola virus VP30 protein that regulate viral replication by interacting with multiple host proteins.

The paper characterizes the spatial and temporal dynamics of fungal communities in grapevines and soils over an annual cycle, identifying core microbiome members and their seasonal succession.

This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.

This paper evaluates HTCC as a potential inhibitor for SARS-CoV-2 and MERS-CoV, highlighting its antiviral activity against highly pathogenic coronaviruses.

This study shows filamentous bacteriophage delays wound healing in Pseudomonas aeruginosa infections by inhibiting keratinocyte migration, supported by a patient cohort study.

The paper designs novel covalent inhibitors against SARS-CoV-2 using a deep Q-learning network and fragment-based drug design, generating 47 lead compounds available in a public repository.

This paper identifies a novel bat coronavirus, RmYN02, with sequence similarities to HCoV-19 and natural insertions at the S1/S2 cleavage site, suggesting a possible recombinant origin for HCoV-19.

This study identifies altered B cell subset homeostasis in IgAV patients, with increased plasmablasts and decreased specific memory B cells, correlating with IgA levels.

This paper identifies parasite-specific tRNA-synthetase interactions as a target for broad-spectrum anti-trypanosomal drugs, validated through natural product inhibitors with no human homolog activity.

This study shows L-BHDU inhibits VZV replication by depleting dTTP, suggesting it targets viral DNA synthesis rather than cellular metabolism.