H. Xu

This study characterizes the flagellar collar in Borrelia burgdorferi, revealing its structural plasticity and essential role in spirochete motility through high-resolution in-situ structures.

Sorbitol promotes early flower bud differentiation in loquat by upregulating the MADS-box transcription factor EjCAL through the ERF12 regulatory pathway.

This study shows PRMT7 inhibition enhances anti-tumor immunity and improves response to immune checkpoint blockade in melanoma by modulating immune cell infiltration and PD-L1 expression.

This study uses normal mode analysis and molecular dynamics simulations to investigate how alginate lyase produces quasi-monodisperse oligosaccharides by analyzing conformational changes and enzyme flexibility.

This study demonstrates that S309-CAR-NK cells effectively target and kill SARS-CoV-2-infected cells, including the D614G mutant, outperforming CR3022-CAR-NK cells in vitro.

This paper reviews PhD career outcome tracking systems and creates a crosswalk tool to map similarities between taxonomies.

The paper investigates the roles of laminin-binding integrins in endothelial morphogenesis using organotypic culture models and identifies distinct functions for 6β1, 6β4, and 3β1.

This study demonstrates that thin-film freeze-drying can convert a Norovirus vaccine into a stable dry powder without antigen loss, enabling cold chain elimination.

The paper identifies meninges as a site for B cell development and CNS-antigen-specific negative selection in mice and NHPs.

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

The paper quantifies how two alternative promoters of the Bicoid target gene hunchback are differentially regulated by Bcd through enhancer-promoter interactions in Drosophila embryos.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

This study shows that hydroxychloroquine increases anxiety and depressive behaviors and alters gene expression in mouse brains, suggesting potential mental health risks.

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

The paper redetermines a protein structure originally solved by MicroED using XRD, comparing the results to assess MicroED's accuracy and limitations.

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

This study identifies SNHG16 as a promoter of renal cell carcinoma proliferation and inhibitor of apoptosis through the miR-1301-3p/STARD9 axis.

The paper examines how plant hydraulic and photosynthetic traits coordinate across species and elevations, finding that hydraulic traits are less plastic and more phylogenetically driven than photosynthetic traits.

The paper refutes a claim that the universal genetic code is optimized for resource conservation by showing the original analysis had methodological errors.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

This study examines how varying calcium concentrations affect the growth and encystment of Scrippsiella trochoidea, finding increased cell density and cyst formation at lower calcium levels, with reductions at higher concentrations.

This study identifies a conserved ubiquitin- and ESCRT-dependent pathway for degrading lysosomal membrane proteins in human and yeast cells.

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

This paper identifies ORF3a as a SARS-CoV-2 viroporin that activates the NLRP3 inflammasome by causing potassium efflux, leading to IL-1β expression and inflammation.

This study investigates the role of WRKY31 and signaling compounds in enhancing insect resistance in Pinus massoniana L. against Dendrolimus punctatus by modulating hormone signaling pathways.

This study shows that IgT is the main immunoglobulin induced in trout skin mucosa during bacterial infection, with SALT serving as a key inductive site.

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

This study characterizes the 24-nt siRNA landscape in rice zygotes, revealing a redistribution towards the vegetative profile and epigenetic resetting before the first embryonic division.

This study shows that altering energy metabolism via IDH gene knockdown affects foraging behavior in termites, with social context modulating these effects.