J. Xu

The paper examines how autophagy and mitochondrial fission impact the Harderian gland in male hamsters under different photoperiods, finding autophagy levels correlate with gland weight changes.

This study compares the efficacy of TBAJ-587 and bedaquiline against a resistant Rv0678 mutant in a mouse tuberculosis model, finding TBAJ-587 more effective and less prone to resistance.

This study identifies AhR and TIEG as a transcriptional axis modulating immune homeostasis in mosquitoes, showing their roles in immune response regulation through gene networks involving sugar metabolism and circadian rhythms.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

This study introduces a computational method to identify genetic regulators of cell identity using epigenetic data across diverse species and validates findings with CRISPR experiments.

The paper develops a method to delete large genomic regions in Nannochloropsis oceanica, showing that non-essential regions can be removed without affecting key traits.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This paper develops a bioelectric neural interface using implantable electrodes and AI to enable intuitive control of a high-DOF prosthetic hand for amputees.

This study identifies a network of ROS, ethylene, and auxin signaling regulating Arabidopsis root growth in response to mechanical impedance.

The paper develops a proteomic strategy to analyze antigen-engaged antibody repertoires, revealing high diversity and specificity of camelid heavy-chain antibodies in binding antigens.

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

This paper designs and tests SARS-BLOCK peptides as antidotes to SARS-CoV-2 by inhibiting spike protein-ACE2 binding and enhancing neutralizing antibody responses.

This study examines how wildfire and its legacy through charcoals affect soil microbial communities in boreal forests over a 29-year chronosequence.

The paper sequenced genomes of Pneumocystis species from different mammals to study host specificity and evolutionary adaptations, revealing insights into the emergence of the human pathogen P. jirovecii.

The paper develops an electrodialysis/phase separation cell to directly extract medium-chain carboxylic acid oil from bioreactor broth, achieving higher efficiency than membrane electrolysis with pertraction.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study shows that SETD2 deficiency disrupts the β-catenin destruction complex, promoting ccRCC formation, and links SETD2-mediated H3K36me3 to Wnt/β-catenin signaling in renal cancer.

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

This study reveals that Smoothened (SMO) activates GLI transcription factors by sequestering PKA catalytic subunits at the membrane, bypassing traditional GPCR signaling mechanisms.

This paper develops a nanoparticle platform for BBB-independent siRNA delivery in TBI, achieving higher brain accumulation and gene silencing through surface chemistry and coating density modulation.

This study investigates the biodegradation of polyester polyurethane by Aspergillus flavus G10 using multiple analytical techniques and identifies conditions that enhance degradation.

The paper tests the Red Queen hypothesis by analyzing two Drosophila de novo miRNAs, finding their fitness contributions vary between species, supporting their different evolutionary fates.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

This study identifies amlodipine as a drug that reduces PD-L1 expression and enhances antitumor immunity by blocking calcium flux and autophagic degradation of PD-L1.

This study develops a SARS-CoV-2 vaccine candidate using virus simulating particles that induces strong neutralizing immune responses with a single dose.

This study evaluates a long-acting tenofovir alafenamide nanofluidic implant in nonhuman primates, showing partial protection against SHIV infection.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

The paper uses scRNA-Seq and scATAC-Seq to analyze human blood cells, identifying proliferative progenitors and epigenetic priming in haematopoiesis.