J. Zhou

This study identifies critical ecological protection areas in Aksu City and Wensu County by simulating human activity impacts and analyzing resistance surfaces across different scenarios.

The paper shows TBK1 phosphorylates TNIP1, activating its LIR-dependent autophagy-mediated degradation, which promotes pro-inflammatory gene expression.

The paper develops a high-throughput method to functionally evaluate natively paired human T cell receptors against multiple pMHCs, validated through affinity-based mapping and sequencing.

LabGym quantifies user-defined animal behaviors using a learning-based approach, providing holistic assessment without pre-defined features or species restrictions.

This paper develops temperature-sensitive nanothermometry probes to measure spatiotemporal thermodynamics of lysosomes and mitochondria in living cells, revealing distinct thermal responses to metabolic perturbations.

The paper shows fish oil nano-emulsions trigger ferroptosis and autophagy in macrophages via catalase-catalyzed superoxide production, leading to oxidative damage.

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

This study identifies distinct genetic determinants in the Omicron spike protein for altered cell entry and antigenic properties, showing they are separable and may affect future variant severity and vaccine efficacy.

This study compares the severity of SARS-CoV-2 Omicron-B.1.1.529, Pango B, and Delta variants in a mouse model, finding Omicron causes less severe disease with lower viral load and inflammation.

This paper introduces self-confocal NIR-II fluorescence microscopy systems for in vivo imaging, improving adjustability and enabling cerebrovascular and hepatic imaging.

This study investigates the biogenesis of mitochondrial outer membrane multi-span proteins using yeast and Om14, showing that both protein factors and membrane properties influence their integration.

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

The paper identifies amyloidogenic peptides in SARS-CoV-2 that are toxic to neuronal cells, suggesting they may contribute to neurological symptoms and long COVID.

This study shows that two pheasant species have experienced recurrent gene flow during speciation, with evidence of long-term gene flow after initial divergence and ongoing contact in recent times.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study shows that malaria parasites use pyrophosphate to power a proton pump essential for ring stage development and transition to trophozoite stage.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This paper demonstrates that the orb-weaving spider uses its web as an acoustic sensor to detect and localize airborne sounds, surpassing the efficiency of known eardrums.

This study shows pVHL regulates TCF/LEF protein stability via ubiquitin-independent proteasomal degradation, revealing a novel mechanism in Wnt/β-catenin signaling.

This study identifies POU-IV as a key regulator of hair cell development in the sea anemone Nematostella vectensis, revealing its ancient role in mechanoreceptor identity.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

This study shows SMC1A promotes gastric cancer progression by enhancing SNAI2-driven EMT, suggesting it as a therapeutic target.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This study shows that TFR1-mediated iron uptake in osteoclasts affects mitochondrial function and cytoskeleton, leading to increased bone mass in female mice.

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.

This study shows that a 3D microenvironment enhances BBB phenotype and function in iPSC-derived microvessels compared to 2D cultures.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.