M. Yang

This study identifies Fbxo7's role in promoting Cdk6 activity to inhibit PFKP and glycolysis in T cells, revealing its impact on metabolism and viability.

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

This study identifies YBX1 deficiency causes mis-splicing in BMSCs, leading to senescence and bone loss, and shows Sciadopitysin can reverse this process.

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

This study identifies a mechanism where 3'UTR-directed mRNA decay inhibits C/EBPβ activation, suppressing senescence in tumor cells and promoting tumor progression.

The study compares antigen-antibody interactions at different states using QDB, showing conformational epitopes dominate interactions, challenging Western blot as a validation tool for IHC and ELISA antibodies.

This study examines the preclinical pharmacokinetics and in vitro ADME properties of GS-441524, showing its stability across species and varying bioavailability, supporting its development as an oral drug candidate for COVID-19.

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

The paper shows that BSMV γb protein targets NbTRXh1 to reduce its reductase activity, impairing SA defense gene expression and enhancing viral movement.

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

This study investigates the biogenesis of propanediol-utilization metabolosomes in bacteria, revealing both 'Shell first' and 'Cargo first' assembly pathways.

This paper introduces PiMS, a method that detects proteoforms up to 70 kDa in human tissue with high spatial resolution, identifying key metabolic enzymes in kidney tissue.

The paper maps immune, endothelial, and neuronal networks in human spleen and lymph node using multiplex imaging, revealing novel cellular localization patterns.

This study shows that IL-4 and IL-13 activation of macrophages induces protective innate memory against mycobacterial infection through enhanced OXPHOS-driven pro-inflammatory responses.

The paper develops genetically encoded fluorescent potassium indicators with tunable binding affinities through structure-guided design and genome mining, showing varying Kd values in vitro and in cells.

This study shows Streptococcus pneumoniae rapidly translocates from the nose through the cribriform plate to the meninges without entering the bloodstream.

This study shows that Zika virus causes placental pyroptosis via GSDME activation, leading to adverse fetal outcomes.

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

This paper develops a cellulose-based method using nanobodies to capture and neutralize SARS-CoV-2 pseudoviruses, showing effectiveness against wildtype and D614G variants.

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

This study investigates the effects of TCA cycle inhibition on redox and amino acid metabolism, revealing ATF4-dependent metabolic rewiring and distinct responses between FH and SDH inhibition.

This study shows that maternal exposure to dibutyl phthalate during pregnancy and lactation leads to increased visceral obesity in adult female offspring without affecting serum glucolipid levels or the PI3K/AKT pathway in muscle.

This paper introduces a new class of iboga alkaloids, oxa-iboga, which show therapeutic efficacy in opioid use disorder without cardiac risks, as demonstrated in rat models.

This study designs and tests a DNA vaccine, INO-4802, which induces broad immunity against multiple SARS-CoV-2 variants in animal models.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

This study identifies and corrects image bias in a touchscreen cognitive task for rodents, improving the accuracy of cognitive assessments by using more similar image pairings.

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study engineers the STING protein as a delivery system to enhance CDN delivery and restore STING signaling in cancer cells.