Q. Wu

This study identifies HAUSP as a deubiquitinase that stabilizes SOX2 in glioma stem cells, maintaining their self-renewal and tumorigenic potential, and shows that targeting HAUSP can enhance GBM treatment.

This study shows that PAA and IAA regulate suberin biosynthesis and Casparian strip development differently in root endodermis, with auxin antagonistically affecting CS formation.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

The paper reports the cryo-EM structure of a glutamate transporter homologue, revealing a conserved chloride channel with two hydrophobic gates that facilitates dual-function transport.

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

This study analyzes the evolutionary patterns of ACE2 binding affinity to SARS-CoV-2 spike protein across 247 vertebrates and identifies key amino acid mutations driving affinity divergence.

The paper identifies non-conventional SUMO2-binding modules on XRCC4 through microarray screening and structural analysis, revealing their role in DNA repair and implications for cancer and gene editing.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

The paper identifies a triresidue motif in GLR3.3's C-tail that interacts with ISI1, essential for wound signaling and jasmonate defense responses in Arabidopsis.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

This study investigates WSSV infection in wild crustaceans in the Bohai Sea, finding high prevalence rates and confirming infection through electron microscopy.

This study shows that inhibiting BET proteins, particularly BRD4, reduces skin fibrosis in scleroderma models by affecting calcium signaling and gene expression.

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

This meta-analysis compares first-generation EGFR-TKI plus chemotherapy to EGFR-TKI alone in advanced EGFR-mutated NSCLC, finding improved ORR, PFS, and OS with the combination, but increased toxicity.

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

This paper maps 3D vascular niches for myeloid differentiation in bone marrow, revealing distinct spatial organization of granulocyte and monocyte/dendritic cell progenitors.

The paper identifies CAG promoter activity as a marker for reprogramming-efficient cells and shows its association with MKL1/SRF activity and cell cycle dynamics.

This study shows that Tomato spotted wilt virus extends the developmental time and increases progeny production in western flower thrips, with a male-biased sex ratio, likely enhancing virus transmission.

The paper identifies Pangolin-CoV as a close relative of 2019-nCoV, showing high genomic similarity and key amino acid conservation in the S1 protein, suggesting it may be an intermediate host.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

This study demonstrates that cross-feeding between Thauera aminoaromatica and Rhodococcus pyridinivorans drives quinoline degradation in a denitrifying bioreactor through 2-hydroxyquinoline as an intermediate.

The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.

This study examines how CO2 responses of photosynthesis in Hippophae rhamnoides leaves vary under different soil moisture conditions using multiple models.

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

The paper maps host-pathogen interactions using quantitative biomarker data to understand disease dynamics in California sea lions, revealing a unidirectional disease trajectory that applies to both longitudinal and cross-sectional datasets.

This study shows that the maize Gβ subunit controls both shoot meristem development and immune responses, with implications for optimizing growth and defense tradeoffs in crops.

This study shows that GLUT1 inhibition reduces growth of RB1-positive TNBC cells with high glycolytic activity and low OXPHOS, suggesting a therapeutic target in this subset.

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.