S. Chen

This paper introduces a 3-D shear wave elastography method using a 2-D row-column addressing array, demonstrating robust performance in both phantom and in vivo studies.

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

This study identifies circSTT3A as a hypoxia-induced circular RNA that stabilizes PGK1 protein to promote breast cancer stem cell formation and chemotherapy resistance.

This study determines the cryo-EM structure of Cx36, revealing structural features that explain its homomeric assembly and cation-selectivity, and provides insights into its role in electrical synapses.

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

This study identifies GIV as a key protein transferred from mesenchymal stromal cells to ER+ breast cancer cells via tunnelling nanotubes, driving aggressive tumor phenotypes.

The paper shows that cysteine is an ancestral Cu(I) ligand in Chlamydomonas reinhardtii, as Zn deficiency disrupts Cu homeostasis and increases cysteine levels, which co-localize with Cu in acidocalcisomes.

This paper develops MUCIG, a CRISPR-Cas13d-based method to silence multiple immunosuppressive genes in the tumor microenvironment, showing efficacy in preclinical models.

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

This study uses in vivo CRISPR activation screens to identify immunostimulatory factors that enhance anti-tumor immunity and develop effective gene therapy combinations.

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

This study investigates genomic and gene expression changes in Staphylococcus aureus after fluoroquinolone exposure, identifying mutations and overexpressed genes linked to multidrug resistance.

The paper identifies NS5A domain I mutations that block HCV virus assembly and shows this effect is mediated through interaction with PKR, an antiviral pathway.

This paper introduces GLPLight1, a genetically-encoded sensor for high spatiotemporal resolution visualization of GLP1R activation, and demonstrates its use in optical control of receptor activation.

This study evaluates tungsten nanoparticle-infused radiopaque absorbable inferior vena cava filters in pigs, showing improved radiopacity but reduced in vivo visibility over time.

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

The paper identifies a proliferative cell population in ER+ metastatic breast cancer using spatial and single-cell transcriptomics, showing its role in estrogen-dependent growth and clinical outcomes.

This study redefines hematopoietic progenitor cells and reformulates the hematopoiesis hierarchy using a transcriptional atlas, identifying key transcription factors and distinct lineage commitment processes.

This paper develops a 3D-printed biocomposite material containing engineered cyanobacteria that respond to chemical stimuli by producing functional outputs like bioremediation and inducible cell death.

This study identifies LRP5 as a selective transporter for unesterified PUFAs, showing its role in mTORC1 inhibition and protection against myocardial injury.

This study shows that active Gαi/o mutants enhance breast cancer metastasis via the c-Src pathway without affecting primary tumor growth.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

This study uses spatial transcriptomics to identify conserved segment polarity genes in Nematostella vectensis, suggesting polarized metameric structures existed in the Cnidaria-Bilateria common ancestor.

The paper identifies a shared ubiquitin-proteasome pathway for degrading TOC and TOM tail-anchored receptors in Arabidopsis thaliana.

This study characterizes pain, functional impairment, and hyperalgesia from NGF injections in a TMD model, revealing sex differences in pain experience.