S. Guo

This study uses Raman spectroscopy and DFT calculations to distinguish three optical isomers of all-trans astaxanthin based on differences in Raman band intensities.

This study identifies and characterizes two CoAT enzymes from bacteria, showing CPB6-CoAT can catalyze both butyrate and caproate synthesis, while BEY8-CoAT only catalyzes butyrate synthesis.

The paper develops a D-2-hydroxyglutarate biosensor using DhdR, which detects D-2-HG in biological samples with high specificity and sensitivity.

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

This study compares bioremediation approaches for anaerobic benzene degradation, finding that nitrate amendment or methanogenic bioaugmentation enhance degradation while sulfate biostimulation does not.

This paper identifies a shared trans flavin-dependent assembly line for 2,2-bipyridine formation in caerulomycin and collismycin antibiotics, revealing sulfur fate differentiation through differential sulfhydryl group treatment.

This paper introduces an automated framework for detecting and tracking ants in videos, achieving high accuracy and speed in both indoor and outdoor environments.

The paper compares HIV integration site distributions in vivo and in vitro to assess the role of oncogene integration in viral persistence during ART.

The paper determines the structural basis of ligand selectivity in MpPA14, a bacterial adhesin lectin, showing it binds specific monosaccharides and polysaccharides through distinct interactions.

The paper identifies a peptide-binding domain in a bacterial adhesion protein and develops ligands that inhibit its function, suggesting potential for disrupting harmful bacterial-host interactions.

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

This study identifies Cx43's role in glioblastoma chemoresistance by activating PI3K signaling, and shows that targeting Cx43 and PI3K{beta} restores temozolomide sensitivity.

The paper examines mRNA expression patterns across nine species to assess the applicability of Haeckel's postulates, finding partial conservation and alignment with terminal edition patterns.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

The paper develops a fluorescent biosensor for L-2-hydroxyglutarate (L-2-HG) using LhgR, a transcription factor that recognizes L-2-HG, and demonstrates its application in monitoring L-2-HG levels in bacterial and human cells.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

The paper shows that Par-3 and dynein mediate polarized endosome movement during asymmetric division, leading to Notch signaling asymmetry in daughter cells.

PET imaging of CCR2+ cells in lung fibrosis identifies therapeutic response in mouse models and shows perifibrotic signal in IPF patients.

The paper identifies CAG promoter activity as a marker for reprogramming-efficient cells and shows its association with MKL1/SRF activity and cell cycle dynamics.

This study shows that deleting Chop/Ddit3 in β-cells reduces ER stress and corrects fatty liver disease in T2D without affecting glucose homeostasis.

This study develops dihydroartemisinin-loaded magnetic nanoparticles to enhance chemodynamic therapy, showing improved ROS production and efficacy against breast cancer cells, including drug-resistant ones.

This paper proposes an electrostatic-interaction-based mechanism for prion protein refolding from PrPC to PrPSc, identifying key steps involving hydrophobic interactions and pH changes.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

The paper introduces a fluorescent reporter to measure cell cycle speed in single cells using one snapshot, demonstrating its application in hematopoietic cells and solid tissues.

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

This study shows that bacterial flagella are not permanent structures, dynamically produced and lost during growth phases, with glucose availability influencing their disassembly.

The paper identifies gene expression differences between human and non-human primate brains at single-cell resolution, revealing rapid evolution in specific cell types.