S. Wu

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

This study reveals polyphyletic origins of clerodane diterpene biosynthesis in Lamiaceae by analyzing genomes and metabolic pathways of three species.

The paper identifies a SHR-IDD-PIN regulatory network that controls minor vein differentiation in rice and C4 grasses by regulating auxin flow through PIN protein expression.

The paper identifies proteomic signatures associated with seroconversion after flu vaccination in a human cohort, revealing links between protein levels and immune response factors.

This study identifies how pyrin-only-proteins inhibit inflammasomes by targeting different filament assembly steps, revealing their target redundancy and inhibition mechanisms.

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

This study identifies AFAP as a bacterial protein that enhances cell adhesion by interacting with host nucleolin, providing insights into the mechanism of A. phagocytophilum-induced cell adhesion in HGA.

The paper identifies energy waves as the mechanism for redistributing heme energy in myoglobin after photolysis, showing they are more efficient than diffusion-based processes.

This study shows that Angptl2 in vascular smooth muscle cells promotes abdominal aortic aneurysm development under inflammation.

This study uses single molecule fluorescence microscopy to observe insulin self-assembly and disassembly, revealing new pathways and how additives influence oligomer formation.

This study uses single-cell and spatial transcriptomic analyses to characterize the prostate tumor microenvironment, revealing immune suppression and high angiogenic activity.

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

This study identifies the EMC complex's role in regulating intestinal stem cell proliferation via the Hippo pathway in Drosophila, showing its negative regulation and evolutionary conservation.

The paper introduces a method to identify the one-dimensional reaction coordinate for protein dynamics, linking structure to function through a generalized work functional.

This study identifies 583 differentially expressed genes in the pituitary of female mice treated with dihydrotestosterone, revealing androgen-responsive pathways and transcriptional changes linked to androgen excess.

This study shows that male mice lacking the pituitary kisspeptin receptor have normal reproductive function despite increased basal FSH levels.

The paper identifies a unique sulfotransferase-involving strigolactone biosynthetic pathway in sorghum involving SbMAX1d and LGS1.

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.

The paper identifies a conserved CTL epitope in the SARS-CoV-2 spike protein that is compatible with most HLA alleles and suitable for evaluating CD8+ T cell responses.

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

This study identifies fluoxetine as a potential therapy for glioblastoma by inhibiting SMPD1 and enhancing temozolomide efficacy, with real-world evidence suggesting improved survival.

The paper identifies a rare fluctuation mechanism that enables protein conformational changes by facilitating energy transfer through specific reaction coordinates.

This study shows that virus-specific memory T cells reside in glioblastoma and can be reactivated to improve survival in a mouse model.

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

This study examines how seasonal climate changes in Guangzhou affect Aedes albopictus development and its susceptibility to DENV-2, finding that mosquitoes can still transmit the virus in winter.