T. Wang

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

This study identifies Grem1-articular cartilage progenitor cells as critical for maintaining joint health, and their loss leads to osteoarthritis, with potential therapeutic targeting of FGFR3.

This paper introduces mNODE, a neural ODE-based method predicting metabolomic profiles from microbial composition, showing superior performance and interpretability across human and environmental microbiomes.

This study evaluates immune responses to an ISFV-based Zika vaccine, showing neutralizing antibodies and T-cells contribute to protection.

This paper develops a human iPSC model of COL4A1/A2 small vessel disease, showing that MMP inhibition rescues ECM abnormalities and mural cell defects.

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

This study shows that lower shear stress promotes neutrophil extracellular traps (NETs) formation, which worsens atherosclerosis by damaging endothelial cells through Piezo1-mediated mechanosensation.

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

This study identifies SREBPs as regulators of intraocular pressure by modulating TM biomechanics through lipogenesis and ECM dynamics.

This study identifies a common mechanism by which bacterial biofilms resist antibiotics through lipid metabolism activation that reduces drug penetration and increases glucose consumption.

This study uses spatial transcriptomics to identify conserved segment polarity genes in Nematostella vectensis, suggesting polarized metameric structures existed in the Cnidaria-Bilateria common ancestor.

The paper identifies CD4+CD28- cytotoxic T cells in SLE patients and shows IL-15 enhances their expansion and cytotoxic function, with JAK3 inhibition blocking this effect.

The paper investigates drug resistance in Klebsiella pneumoniae, finding that rcsB regulates capsule formation, which affects drug resistance.

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

This study develops an FcRn-targeted mucosal vaccine that reduces SARS-CoV-2 infection and transmission in mice and hamsters by inducing protective immune responses in the airways.

The paper maps single-cell lysis probabilities to population-level biomass dynamics during antibiotic treatment, showing how filamentation extent influences lysis and validates this with experiments.

This study examines renal markers in autoimmune diseases, finding that autoantibodies significantly affect marker levels and are more frequent in severe renal damage.

This study examines the prevalence and risk factors of HIV-1 associated thrombocytopenia and its link to neuroinflammation in a hospital in western China.

This study develops a computational pipeline combining metagenomics and metaproteomics to identify proteins' metabolic and ecological roles in gut microbiomes using simulated and real data.

The paper presents a single-cell transcriptomic atlas of human inner ears, revealing increased regeneration in diseased utricles and new cell type markers.

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

This study identifies recurrent DNA methylation alterations in primary non-small cell lung cancer samples from smokers and never-smokers, highlighting differences in hypomethylation patterns and their association with oncogenes and transcription factor binding motifs.

The paper evaluates DLP 3D printing for PDMS microfluidics, optimizing parameters and demonstrating applications in cell viability, drug response, concentration gradients, and live-cell invasion.

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.

The paper shows that embryonic vitamin D deficiency in HSCs leads to diabetes in mice by altering epigenetic pathways and macrophage function.

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

This study identifies Tmem100 as a lung-specific endothelial gene through single-cell RNA-sequencing analysis.