T. Wang

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

This study shows human microglia can be reconstituted in the brain of hu-BLT mice with hIL34 transgene and support HIV-1 infection, highlighting their role in CNS HIV-1 pathogenesis.

This paper introduces a water-reward task assay to quantify mutualistic cooperative behavior in mice and provides detailed procedures for its implementation.

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

The paper analyzes the saccharide composition of onion outer epidermal walls using multiple methods and finds that homogalacturonan makes up about 50% of the polysaccharides.

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

This study examines AV nodal function in giraffes during atrial fibrillation and ventricular tachycardia, finding prolonged PR intervals and slow ventricular responses consistent with unique cardiovascular adaptations.

This study identifies a de novo germline mutation in Dusp10 that accelerates autoimmune diabetes in NOD mice by increasing susceptibility through CRISPR validation and PD-L1 expression analysis.

The paper establishes a SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells expressing ACE2 and TMPRSS2, showing good correlation with other assays.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

The paper identifies KIF1C as a motor transporting APC-dependent mRNAs to cell protrusions, showing its dual role in RNA transport and clustering.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

TailTimer automates the rodent tail immersion assay by recording tail withdrawal latency and water temperature, improving reproducibility and detecting genetic differences in thermal pain sensitivity.

This study identifies miR775 as a regulator of leaf size in Arabidopsis by silencing GALT9, a galactosyltransferase that affects cell wall pectin levels and elasticity.

This study uses deep learning and high-resolution satellite imagery to detect and count African elephants in heterogeneous landscapes, achieving accuracy comparable to human detection.

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

This study shows that the PRRA insert in SARS-CoV-2 and raTG13 Spike proteins affects ACE2 usage across species, altering cellular tropism.

The paper identifies new integrin antibodies that inhibit fibrosis progression in lung injury models and show superior in vitro activity in fibroblasts.

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

The paper analyzes canine cancer mutation rates across breeds and cancer types, finding a positive correlation with TP53 mutations and a breed-specific mutation signature in Golden Retrievers.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.

The paper predicts hundreds of new cross-feeding interactions in the human gut microbiome using an ecology-based computational method called GutCP, supported by genome annotation evidence.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

The paper shows that local RNA translation of RAB13 at cellular protrusions is required for full activation of the GTPase and efficient cell migration, mediated by its association with RABIF.

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

This study evaluates antibody responses to different SARS-CoV-2 spike protein antigens in rabbits, finding that the RBD antigen elicited higher affinity and titer neutralizing antibodies.