T. Wang

This study develops synthetic transcription factor sponge systems to regulate gene expression in E. coli for metabolic engineering, achieving a 16-fold increase in arginine production with genetic stability.

The paper investigates how regulatory light chains (RLCs) influence the functional diversity of myosin-II isoforms by swapping RLCs with different myosin heavy chains and measuring changes in actin filament sliding velocity.

The paper models CRISPR-mediated host-virus interactions and shows empirical systems exhibit weighted-nested protection networks indicative of host suppression of virus diversification.

This study evaluates 19 antiviral drugs against SARS-CoV-2 infection and finds remdesivir to be the most effective, while others show limited or no direct antiviral activity.

This study shows that polyamine homeostasis in T cells is regulated by de novo synthesis and salvage pathways, affecting proliferation and function, with implications for inflammatory and autoimmune diseases.

This meta-analysis compares first-generation EGFR-TKI plus chemotherapy to EGFR-TKI alone in advanced EGFR-mutated NSCLC, finding improved ORR, PFS, and OS with the combination, but increased toxicity.

The paper analyzes urine proteome changes in α-synuclein transgenic mice to identify proteins associated with Parkinson's disease progression.

The paper identifies differential proteins in urine of tumor-bearing mice, showing early biomarker potential for melanoma and prostate cancer.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

The paper introduces a computational framework to analyze mobile genetic element persistence in microbial communities and derives a metric to predict their abundance and persistence.

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study shows that Mitofusin 2 suppresses Rac activation to regulate neutrophil adhesive migration and actin cytoskeleton dynamics.

The paper develops an intermediate-scale model to describe microbial cross-feeding interactions, showing it accurately captures community dynamics and species coexistence in experimental data.

This study investigates whether CatSper channels in human sperm are activated by cAMP and PKA signaling, finding that cAMP analogs activate them extracellularly and PKA inhibitors act off-target.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

This study translates dog-to-human aging by identifying conserved epigenetic changes, showing methylation patterns align physiological milestones across species.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study examines how hearing sensitivity changes with age in red-eared slider turtles, finding frequency-specific developmental patterns and age-related shifts in auditory thresholds.

This study shows that overexpression of PGRB promotes ovarian tumor development in mice, while PGRA reduces tumor frequency, highlighting the role of PGR isoforms in hormone-dependent neoplasia.

This study identifies miR-216a as a pancreas-specific miRNA that regulates cell proliferation and function in both endocrine and exocrine cells, with implications for diabetes and pancreatic cancer.

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

The paper shows that long-term potentiation increases extrasynaptic exocytosis of GluN2A-containing NMDA receptors, primarily controlled by SNAP-23.

This study identifies PeGATA transcription factors in moso bamboo and shows they regulate shoot growth and rhizome development via GA signaling pathway.

The paper models the human gut microbiome as a multi-level trophic system, predicting four trophic levels and their metabolic interactions, which align with observed fecal metabolomes.

This study shows N-acetyl cysteine (NAC) alleviates Coxsackievirus B-induced myocarditis by inhibiting caspase-1 and viral proteases, offering a potential therapeutic option.

This study uses full-length transcriptome sequencing to analyze salt tolerance mechanisms in Spartina alterniflora and identifies key genes and regulatory networks involved in stress response.