X. Chen

This study shows that non-core RAG regions reduce off-target V(D)J recombination and maintain genomic stability in BCR-ABL1+ B-ALL by improving RAG cleavage accuracy.

This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.

This paper proposes AGAN, a GAN-based method for filling missing data in cardiac disease datasets, improving data quality and downstream classification accuracy.

This study identifies a diverse range of viruses in oil reservoirs and their ecological roles in regulating microbial communities and biogeochemical cycles.

This paper develops a method for detecting cannabidiol (CBD) at picomolar levels using gold nanoparticles functionalized with chemically induced dimerization binders, achieving high sensitivity and specificity in biological samples.

This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.

This study curates a dataset of influenza HA antibodies and develops an explainable language model to predict antibody specificity, identifying and validating HA stem antibodies.

This paper genetically engineers mesenchymal stem cells to act as a nitric oxide reservoir, enhancing therapeutic efficiency in acute kidney injury by precise spatiotemporal NO release.

This study identifies O-GlcNAcylation of YTHDF2 at Thr-49 as a regulator of ERK-dependent phosphorylation and tumor growth in lung carcinoma.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

This paper develops a recombinant spider silk-based 3D culture system for breast cancer cells, showing improved cell viability and modulation of cancer-related biological processes.

This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

This study develops a multiscale model showing that polymerization force-regulated actin-Arp2/3 interactions enable cells to adaptively migrate through heterogeneous ECMs via opposing feedback mechanisms.

This study shows FDX1 is essential for embryonic development and lipid homeostasis, with knockout mice showing embryonic lethality and lipid droplet accumulation.

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

This study shows that combining MEK inhibition and Pparg activation eradicates muscle-invasive bladder cancer in a mouse model by reversing tumor differentiation and inducing apoptosis.

This paper introduces a nano-sieve device for MRSA purification and detection using CRISPR, achieving a 15x concentration factor and 100 CFU/mL LOD.

This study investigates secondary metabolites in cold seep microbiomes using metagenomic, metatranscriptomic, and metabolomic data, revealing diverse biosynthetic gene clusters and their potential ecological roles.

This study measures time-dependent material properties of human uterine layers in nonpregnant and third-trimester pregnant tissues using nanoindentation.

This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.

This study maps N-glycosylation sites in SIDT1 and SIDT2 and shows their role in RNA uptake, cell surface expression, and protein stability.

The paper develops a machine learning tool using artificial confocal microscopy to assess embryo viability by detecting nucleus features and classifying embryos into healthy/intermediate or sick categories.

This study uses an automated system to analyze social behavior in groups of mice, revealing social rules and the impact of neuronal plasticity on social interactions.

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

This study investigates the colonization history of Dianthus carthusianorum using genome-wide SNPs and ABC-RF to reveal sequential East-West colonization events with restricted gene flow.

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

This study identifies hypermutated IGHV3-53/3-66 antibodies from breakthrough infections that broadly neutralize SARS-CoV-2 variants including BQ and XBB.

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.