X. Chen

PENet is a deep learning model that automatically extracts and encodes morphological features into hash codes, showing effectiveness in feature extraction and image retrieval across beetle datasets.

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

This study shows that FTO, through lactylation-driven m6A modification of CDK2, worsens diabetic retinopathy by promoting angiogenesis and inflammation, and presents a nanotherapeutic approach to inhibit FTO.

This paper introduces ADT-007, a novel pan-RAS inhibitor that effectively blocks tumor growth in mouse models of GI cancer by targeting RAS activation and inducing apoptosis.

The paper develops a method to track transcriptome differences in clonal expansion and shows constrained expression noise dynamics during cell divisions.

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

This study identifies the soluble guanylyl cyclase (sGC) pathway as a target for castration-resistant prostate cancer (CRPC) treatment, showing that riociguat inhibits CRPC growth and enhances radiation response.

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

This study investigates Senicapoc, a KCNN4 inhibitor, and finds it delays mammary tumor development and slows tumor growth in mouse models, suggesting potential for breast cancer prevention and treatment.

The paper shows that inhibiting HDACs selectively targets NRF2-activated lung adenocarcinoma by altering chromatin and metabolic pathways.

This paper introduces LOCA-ULM, a deep learning method for ultrasound localization microscopy that improves microbubble detection and localization accuracy in vivo and in silico.

This study shows that varying light intensity affects social interactions and collective behavior in schooling fish by altering their responses to obstacles and group motion patterns.

This study identifies three TCS proteins in Brucella ovis that work together to confer resistance to cell envelope stressors and support intracellular replication.

The paper identifies survival-associated ion permeome genes across 29 cancer types and shows their role in glioblastoma aggression through functional experiments.

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

This study identifies RCF1 as a key player in miRNA biogenesis and RNA splicing in Arabidopsis by showing its role in pri-miRNA processing and splicing defects in a mutant.

This study identifies Sox11 as a marker of differentiating muscle satellite cells, showing reduced expression in quiescent and aged cells, but finds it dispensable for muscle development and regeneration.

This study identifies three PRC barrel proteins in Haloferax volcanii essential for archaeal cell division, showing their conservation and role in division across haloarchaea.

This study constructs a pan-cancer prognosis risk model using ADME genes under low press and hypoxia conditions, finding lower risk scores correlate with better survival in 25 cancer types.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

This paper introduces smART FRET, a method that improves distance sensitivity in single-molecule studies by using acceptor rise time, enabling both closer and longer distance measurements with higher precision.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study shows that loss of the kinase Atg1 in yeast increases maintenance energy requirement and accelerates cell death, suggesting autophagy plays a key role in cellular energetics during aging.

This study shows XBB.1.5 has higher ACE2 binding and moderate antibody evasion, contributing to its increased transmissibility compared to other variants.

The paper identifies keystone taxa in activated sludge microbial communities that enhance stability but reduce function, highlighting the trade-off between stability and performance.

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

This study shows that lower shear stress promotes neutrophil extracellular traps (NETs) formation, which worsens atherosclerosis by damaging endothelial cells through Piezo1-mediated mechanosensation.

The paper assesses the protective effect of neutralizing antibodies from prior Omicron BA.5 infection against symptomatic reinfection with BA.5, BF.7, CH.1.1, and XBB.1.5 subvariants, finding a strong correlation between antibody titers and reduced reinfection risk.