X. Chen

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

The paper identifies two ubiquitin-activating systems in plants, showing that one E1 plays a major role in plant immunity by differentially charging ERAD-associated E2s for ER stress tolerance.

The paper shows that PFOR supports aerobic photomixotrophic growth in cyanobacteria by utilizing ferredoxin instead of NAD(H), saving Gibbs free energy and decelerating metabolism.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

This paper uses micro-CT to study the appendage structure of Pygmaclypeatus daziensis, revealing its heteronomy and suggesting an ancestral exopodite morphology in Artiopoda.

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.

This study shows that PIK3CA mutations drive hepatocarcinogenesis independently of RASSF1A status, with early Galectin-1 upregulation and synergistic therapeutic effects of PIK3CA and Galectin-1 inhibitors.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This paper reviews preclinical studies showing that inhibiting cholesterol esterification reduces tumour burden across cancers, with SOAT inhibitors like avasimibe showing promise.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

This paper develops a deep-learning enhanced on-chip DSLM system for high-speed volumetric imaging of neural activity in moving Drosophila larvae.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

This paper identifies and characterizes a phage-derived depolymerase, Dpo71, which enhances antibiotic efficacy and immune response against multidrug-resistant Acinetobacter baumannii.

The paper shows that microtubules inhibit miR165/6 loading into AGO1 in the cytoplasm, enabling its non-cell autonomous movement in Arabidopsis roots.

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

This paper presents a deformable microfluidic device using microbeads to separate plasma and retrieve blood cells, supported by imaging and computational modeling.

This study identifies a p53-like transcription activation domain in PIF3 and shows that PHYB binding inhibits its activity, revealing a photoresponsive transcriptional switch in Arabidopsis.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study shows that chemo-mechanical cues influence chromatin organization in connective tissue cells, with disease disrupting this relationship.

This study identifies and validates SARS-CoV-2 CD8+ T cell epitopes, demonstrates their cross-presentation, and shows the efficacy of peptide vaccines in transgenic mice.

This study uses photoelectrochemistry to investigate electron transfer pathways in cyanobacteria, showing the periplasmic space's role in exoelectrogenesis and the contribution of type IV pili to electrode adherence.

The paper presents cryo-EM structures of the human calcium-sensing receptor in inactive and active states, revealing structural changes during activation.