X. Zhou

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

This paper uses human ventricular electromechanical modelling to explain clinical phenotypes in acute and chronic myocardial infarction, showing that ionic remodelling impacts ECG changes and ejection fraction.

This paper introduces single-objective evanescent scattering microscopy for label-free single protein imaging and binding kinetics quantification with high spatiotemporal resolution.

This study examines concurrent tau pathologies in FTLD-TDP, finding common co-occurrence of PART and ARTAG, and rare cases of AGD and CBD.

This study shows that diet, particularly pollen polysaccharides, has a greater impact on shaping gut microbiomes in Asian honeybees than genetics.

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

This study shows fibroblasts sense space and regulate macrophage numbers via growth factor production.

The paper reports the structure and function of PurTCp, a NAT family transporter from Colwellia psychrerythraea, showing it transports purines via H+-dependent mechanism and identifies a critical aspartate residue.

This study investigates the role of individual hydrogen bonds in facilitating the self-adherence of the TDP-43 low complexity domain.

The paper identifies recurrent mutations in low complexity domains that introduce single hydrogen bonds, and shows that methylation can restore normal protein function.

This study determines the structure of Drosophila P5CS filament, revealing how filamentation coordinates GK and GPR domains for catalysis.

This study evaluates variant-specific LNP-mRNA vaccines against SARS-CoV-2, showing differential neutralization and immune responses in animal models.

This study evaluates off-target mutations caused by high-activity adenine base editors in rice, finding that TadA9 variants and CRISPR/SpCas9n-NG increase off-target A>G SNVs, with RNA mutations clustering more than DNA mutations.

This study examines mitochondrial dysfunction in a MAFLD cell model, identifies gene expression changes, and suggests potential therapeutic targets.

This study reports crystal structures of SARS-CoV-2, SARS-CoV, and MERS-CoV main proteases bound to PF-07321332, revealing conserved ligand-binding sites and insights into inhibitor mechanism.

The paper analyzes gut microbiota in Saudi populations to identify associations with type 2 diabetes, finding increased Firmicutes abundance and a higher Firmicutes/Bacteroidetes ratio in diabetics.

This paper introduces a novel lightsheet scattering microscopy technique to visualize long-term cell-ECM interactions in 3D without photobleaching.

This study shows that Verbena officinalis extract reduces inflammation and enhances NK cell killing efficiency, with Verbenalin specifically improving viral infection response.

This paper develops a pipeline to identify single-copy protein-coding genes for accurately quantifying sequence-discrete populations in microbial communities, validated using Gilliamella in honeybee guts.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study investigates how grafting affects anthocyanin synthesis in grapevines by analyzing metabolomic and transcriptomic profiles across different grafting conditions.

This study shows that adding a C-terminal tail to the tailless murine GnRHR impairs fertility by reducing FSH production and ovarian follicle development.

This paper develops a microwave heating-based method to rapidly synthesize DNA/RNA-AuNP conjugates with high stability and broad applicability.

The paper shows 24-nt phasiRNAs move from tapetal cells to meiocytes and other somatic cells in maize anthers.

This study shows that the cGAS variant rs610913 maintains a baseline antiviral state, slightly altering susceptibility to viral infections without gross phenotypic differences.

This study uses super-resolution microscopy to observe and quantify the heterogeneous growth of amyloid spherulites in real-time, revealing anisotropic growth pathways and energy landscapes.

This study shows that polysorbate 80 affects insulin aggregation kinetics and physicochemical properties of formed amyloid-like spherulites.

This study shows that naked mole-rats lack thymic involution until midlife and have ectopic cervical thymi with distinct T cell composition compared to mice.

This study identifies how Mycoplasma ovipneumoniae evades alveolar macrophage clearance by altering apoptosis, phagosome maturation, and autophagy in sheep.

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.