Y. Chen

The paper shows that loss of PABPC1 increases PABPC4 levels and alters key transcriptional regulators in HEK293 cells.

This study identifies Paip2 as a protein that interacts with PABPC1 on mRNA and may help PABPC1 detach from mRNA during deadenylation.

The paper shows PABPC1 is essential for P-body formation despite not being present in P-bodies, and demonstrates GW182's role in mediating this process.

The paper identifies and characterizes a novel sulfur-containing aminolipid in marine roseobacters, showing its role in biofilm formation and widespread distribution in Tara Oceans metagenomes.

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

This study identifies SNHG1 as a regulator of LPS-induced acute lung injury by modulating the miR-421/TIMP3 axis in A549 cells.

This study develops an OMV-based vaccine using Salmonella Typhimurium to deliver Shigella flexneri 2a O-polysaccharide antigen, showing protection against lethal pulmonary infection in mice.

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

The paper identifies and characterizes a novel adipocyte population with active Wnt/β-catenin signaling that influences beige fat formation and glucose homeostasis in mice.

Beeporter enables non-invasive, high-throughput detection and quantification of DWV infection in honey bees using GFP-tagged virus and smartphone imaging.

This study investigates how TRPV4 ion channels in keratinocytes mediate UVB-induced inflammation by activating inflammasomes and MAPK signaling, leading to IL-1β secretion and pain.

This study identifies tissue-resident CD4+ T helper (TRH) cells that support local B and CD8+ T cell memory responses in the lung after influenza infection.

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

This study investigates the neuroprotective role of CTRP1 in TBI rats, finding it reduces inflammation and modulates autophagy through mTOR activation.

This study investigates the toxic effects of 1,4-dioxane in mice using histopathology and multi-omics approaches, finding DNA damage counterbalanced by repair mechanisms with no systemic metabolic impact.

This study designs non-covalent SARS-CoV-2 Mpro inhibitors using structure-based design and Ugi-4CR reactions, identifying 23R as the most potent compound with antiviral activity.

This study identifies 412 foamy viruses from 6 lineages in amphibians, revealing co-evolutionary patterns and cross-species transmission across Paleozoic to Cenozoic eras.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

This paper develops a method to diversify therapeutic antibodies by mimicking natural B cell processes in mice, resulting in new antibodies with altered functions.

Overexpressing EiKCS from goosegrass in rice increases polyamine levels and enhances paraquat tolerance through improved antioxidant capacity and photosynthesis.

This study determines the structure of SARS-CoV-2 Mpro with calpain inhibitors and analogues, revealing new insights for developing dual inhibitors against Mpro and cathepsin L.

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

This study shows that maternal parity influences gut microbiome changes during pregnancy and affects offspring microbiota composition in pigs.

This study identifies EBV miRNAs that regulate type I interferon responses in B cells and pDCs during early infection, dampening IFN- secretion.

This study develops mEnv liposomes (MELs) as a vaccine platform that elicits HIV broadly neutralizing antibodies without extra proteins, showing neutralization of tier 2 HIV isolates in rabbits.

The paper shows that worker honey bees cannibalizing DWV-infected pupae transmit the virus to other bees through trophallaxis, spreading DWV without Varroa mites.