Y. Chen

This paper uses GPT-4 to extract data from synthetic biology papers, creating structured datasets that improve ML predictions for yeast fermentation.

This paper identifies the Rnf complex as essential for Fusobacterium nucleatum's metabolic adaptation and virulence, showing its role in amino acid catabolism, biofilm formation, and pathogenesis in a mouse model.

This study shows that deleting the Gclc gene in the endocrine pancreas of mice leads to severe diabetes due to oxidative stress and islet dysfunction.

This paper extends a 1D model of cell motility to 2D, showing that the interplay between mechanosensitive adhesions and membrane tension can lead to different motility modes like gliding and zigzagging.

This study compares the genetic architecture of skeletal armor traits in two stickleback species, finding more polygenic and heterogeneous variation in nine-spined sticklebacks.

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

This study shows Yarrowia lipolytica can metabolize cinnamic and p-coumaric acid to 4-hydroxybenzoic acid via multiple pathways involving a trans-cinnamate 4-monooxygenase.

This study investigates carbon catabolite repression in Pseudomonas putida M2 during simultaneous sugar and aromatic co-utilization, revealing simultaneous repression by sugars and aromatics and the role of crc and small RNAs.

The paper uses proteomics to compare DIPG cells in co-culture with brain organoids to control conditions, finding changes in adhesion, DNA synthesis, and dendrite growth pathways.

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

This study shows that ZnF2-defective GATA3 mutations impair LLPS and DNA binding, reducing breast cancer progression and enhancing type I IFN signaling.

This study identifies MSMEG_0317 as essential for mycolic acid transport in Mycobacterium smegmatis, showing its role in maintaining the outer membrane structure.

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

This study identifies non-redundant roles of CLCa and CLCb in epithelial lumen formation through analysis of knockout mice and cell line models.

This study assesses genetic diversity in critically endangered Chieniodendron hainanense populations using GBS and SNP methods, finding limited diversity and weak genetic differentiation.

This study shows that the COP9 signalosome promotes neointimal hyperplasia via deneddylation and CSN5-mediated nuclear export of p27 in vascular smooth muscle cells.

This study investigates the roles of two 14-3-3 proteins in Fusarium sacchari, showing redundancy and distinct functions in pathogenicity and development.

This study identifies E2F1 as a transcription factor regulating CCHCR1 expression through a bidirectional promoter with TCF19 during the G1/S cell cycle transition.

This paper introduces a deep learning framework for fast fluorescence lifetime imaging under low-light conditions, achieving robust results with few photons per pixel.

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

This study shows that intestinal Surf4 deficiency reduces lipid absorption, secretion, and metabolism in mice, leading to weight loss and altered lipid levels.

This study engineered Yarrowia lipolytica to overproduce nervonic acid through metabolic pathway modifications, achieving high titers and purity.

The paper shows EGFR inhibition increases ALPP surface expression in lung adenocarcinoma, enhancing the effectiveness of ALPP-ADC therapy.

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

This study uses plastome data to analyze the genetic diversity and phylogeny of Cibotium species in China, identifying cryptic species and lineage differentiation to aid conservation and breeding efforts.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

This study identifies a C-terminal residue critical for SARS-CoV-2 spike protein trafficking and virion assembly, offering insights for vaccine design.

The paper identifies long-B prokaryotic Argonaute systems as cell suicide mechanisms that use effector proteins to eliminate invading nucleic acids through abortive infection.