Y. Li

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

The paper shows ABHD6 selectively regulates metabotropic-dependent 2-AG production via DAGL and calcium, unlike ionotropic-dependent increases.

The paper develops chemical labeling strategies to tag lipid-modified RNAs and identify new regulatory enzymes involved in prenylation.

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

The paper shows hypoxia induces a long-lasting suppression of type I interferon and antigen presentation in breast cancer cells, enhancing metastasis and being reversible with HDACi and immunotherapy.

The paper identifies IL-13-programmed airway tuft cells that produce PGE2, which enhances CFTR-dependent mucociliary function in allergic airways.

The paper identifies enhancer RNAs in oesophageal adenocarcinoma using RNA-seq and open chromatin maps, revealing new deregulated pathways and their clinical relevance.

This paper shows that combining XPO1 inhibitor selinexor with KRAS G12C inhibitors enhances antitumor effects in preclinical models of KRAS G12C mutant cancers.

This paper develops a framework for generating device-specific optimal PSFs for 3D super-resolution imaging using deformable mirrors, demonstrating superior performance over conventional PSFs.

This study conducts a meta-analysis of lithium's effects on plants, finding varied toxic responses based on exposure medium, source, and concentration.

This study shows that corneal stromal stem cell secretome promotes scarless corneal wound healing and rescues sensory nerves by reducing inflammation, fibrosis, and complement-mediated cell death.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

This study identifies FtMYB102 and FtbHLH4 as a transcriptional complex that promotes rutin accumulation in Tartary buckwheat by inducing CHI expression.

The paper investigates two filament structures of E. coli PRPS resolved by Cryo-EM, revealing how ligand binding modulates allosteric inhibition and PRPP production.

This study characterizes the biophysical, molecular, and proteomic properties of EVs from retinal organoids and compares them to hUCMSC EVs, showing superior therapeutic potential for retinal disorders.

This paper describes a method to generate and expand high-grade serous ovarian cancer organoids with improved success rates and reports their drug response correlation with clinical outcomes.

This study compares antibody neutralization efficacy against SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, BA.2, and BA.3, showing increased resistance and the benefit of vaccine boosters.

This study identifies Hippo signaling pathway activation as an antiviral response to SARS-CoV-2 infection and shows pharmacological targeting of the pathway can reduce virus replication.

This study shows CCR4 and CCR7 differentially regulate thymocyte subset localization and central tolerance outcomes through distinct mechanisms and APC interactions.

This study develops a miniaturized ultrasound transducer for full-mouth oral health monitoring, demonstrating high-resolution imaging and accurate gingival thickness measurement.

The paper shows that phase-separated TRB proteins aggregate with PRC2 to enhance Polycomb silencing in plants.

The paper sequenced full-length transcriptomes of four reef-building corals to uncover molecular mechanisms of calcification, symbiosis, and circadian genes.

MRSCloud is a cloud-based tool for simulating MR spectroscopy basis sets, achieving high accuracy and reduced runtime compared to existing methods.

This study shows that lncRNA Malat1 restricts Th17 cell IL-17A production by regulating a bivalent super-enhancer, thereby controlling intestinal inflammation resolution.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

This study shows that asymmetric ABA response in tomato root tips mediates proton efflux and cell elongation, driving hydrotropic bending toward water.

The paper was withdrawn due to lack of author consent and is not intended for citation.

This study investigates the synergy between XPO1 inhibitor selinexor and gemcitabine-nab-paclitaxel in pancreatic cancer using cellular and mouse models, showing improved survival and molecular changes.

The study evaluates algae community distribution in the Hulanhe Wetland, finding that TN and TP are key environmental factors influencing algae composition.