Y. Li

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

This study observes and attributes intermittent bioluminescence blinking in native bacteria to stochastic gating of Na+/H+ antiporters, revealing their dynamic behavior in living cells.

This study shows PME-1 demethylates PP2A holoenzymes and inhibits substrate recognition through structural interactions with the B56 subunit, revealing mechanisms of PME-1 activity and its role in p53 signaling.

This study shows that APOE deficiency in human iPSC-derived cerebral organoids disrupts lipid homeostasis and affects cholesterol biosynthesis and neurogenesis.

This paper introduces a method to improve signal-to-background ratio in 3D-STED nanoscopy using dynamic phase switching with adaptive optics.

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

This study directly observes bacterial spreading in soil-like conditions, showing surfactant-producing bacteria generate corner flows that influence their movement and bioremediation potential.

This paper introduces an algorithm called cryoRL that uses reinforcement learning to optimize cryo-EM data collection, outperforming human operators in efficiency and image quality.

The paper develops MILL, a technique to rapidly create 3D micro-patterned flow channels that mimic in vivo fluid shear stress environments, enabling real-time study of cell adhesion and translocation.

The paper automates an associative learning and long-term memory test in larval zebrafish using tracking software to improve data acquisition efficiency.

This study investigates the role of Serglycin in liver hepatocellular carcinoma, showing its association with tumor microenvironment and prognosis.

This study identifies the Hdc GC box as essential for Hdc gene transcription, histamine synthesis, and anaphylaxis in mice and human mast cells.

This study identifies enhancers regulating TNF gene transcription in human macrophages upon TLR3 stimulation and shows their functional importance.

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

This study develops a method to fluorescently label Tau protein at its C-terminus to avoid disrupting its microtubule-binding region, showing no significant effect on its aggregation properties.

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

The paper introduces A-PoD, a deconvolution algorithm for super-resolution SRS imaging, achieving 52 nm resolution and enabling nanoscopic analysis of biomolecules and metabolic dynamics.

This study uses single-cell RNA sequencing to show that aged alveolar macrophages exhibit a senescence-like phenotype linked to reduced CBFβ expression and impaired self-renewal.

The paper identifies PPIX-binding proteins and shows that increased heme/porphyrin synthesis promotes ferroptosis distinct from canonical ferroptosis, with PRDX3 modulating this process.

This paper introduces a new humanized mouse model using cord blood-derived CD34+ cells and pediatric thymic tissue that supports functional T cell development and HIV infection and persistence.

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

This study develops Nm-VAQ, a qPCR-based method to precisely validate and quantify RNA 2'-O-methylation sites, demonstrating its application on rRNA.

This study compares scRNA-seq and snRNA-seq of human pancreatic islets, identifying new gene markers and three β-cell subpopulations with distinct transcriptional profiles.

This study shows gliotransmission via adenosine signaling determines axon regeneration in specific neuronal types, with implications for CNS repair.

The paper introduces NAD+ sensors to measure subcellular and clinical NAD+ dynamics, revealing NAD+ redistribution effects of -GPC in live cells.

This study identifies self-organized canals in bacterial colonies that enable long-range directed transport of cells and vesicles, driven by biosurfactant-mediated fluid flows.