Y. Ma

This study systematically evaluates dipeptidyl inhibitors of SARS-CoV-2 main protease, identifying compounds with high antiviral potency and low cytotoxicity.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

This study shows that reduced Prolyl oligopeptidase (POP) and its product Ac-SDKP contribute to ovarian fibrosis in PCOS mice by altering MMP-2 and TGF-β1 expression.

This study uses super-resolution microscopy to analyze platelet morphology, ultrastructure, and function in acute ischemic stroke patients, revealing structural and functional changes and demonstrating the utility of the technique for assessing antiplatelet drugs.

This study identifies DEK1 as a regulator of cellulose synthesis and cell wall mechanics in Arabidopsis thaliana.

This study investigates how hormones regulate promoter activities of CsPT1 and CsPT4 genes and how salicylic acid affects cannabinoid biosynthesis in Cannabis sativa.

This study reports the formation mechanism of twinning β-form anhydrous guanine microplatelets in scallop eyes, revealing an intermediate amorphous phase and a two-step crystallization process.

This study identifies AdgB and AdgI as key proteins in the Variovorax auxin-degradation operon, revealing their roles in IAA uptake and conversion to oxIAA, and demonstrates the operon's potential for IAA regulation in E. coli.

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

This study investigates how nitrate input affects iron and arsenic mobility in aquifers by examining microbial processes in microcosm experiments.

This study develops a mouse model of PTEN-mutated brainstem glioma and finds that ATM deletion does not enhance radiation efficacy in this model.

The paper identifies native peptide substrates for bacterial Hsp70 DnaK, finding conserved and divergent binding properties among them, with VP5 showing potential as an antibacterial lead.

The paper introduces siEVPRA, a method to detect proteins, mRNAs, and miRNAs in single EVs using fluorescence microscopy, showing high sensitivity and clinical utility in GBM samples.

The paper identifies Hippo kinases as inhibitors of PI3K alpha, showing epinephrine activates these kinases to suppress insulin signaling and glucose metabolism.

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

This study identifies differential proteins and pathways affected by BF-TK/GCV treatment in gastric cancer cells, showing its anti-metastatic effects through proteomics and functional assays.

This study identifies a point mutation in the CHLI gene of strawberry that affects leaf color and metabolism by reducing chlorophyll and flavonoid levels and altering light sensitivity.

This study links gut microbial depletion of Lachnospiraceae genera to lower HDL-C and hypertension in a high-calorie diet population, suggesting HDL-C as a mediator.

This study shows that fatty acid β-oxidation and TLR4 signaling drive melanoma progression by altering histone acetylation and inflammatory gene expression.

This paper shows that ascorbic acid-derived carbon dots (VCDs) improve circadian rhythm and reduce hyperactive behavior in a zebrafish ADHD model caused by per1b mutation.

This paper develops a photoswitchable ligand for β1-adrenoceptor that enables light-controlled cardiac rhythm management in zebrafish larvae.

This study shows that metabolic interactions influence the spread of plasmid-encoded antibiotic resistance during microbial range expansion by affecting spatial positioning and conjugation rates.

The paper examines dynamic changes in nucleolar structure and nucleoli-centromere interactions during development and in cancer, finding that these changes correlate with cell differentiation and malignancy.

This paper develops a self-healing hydrogel that mimics brain parenchyma viscoelasticity to promote healing of brain lesions in mice.

This study identifies lipid droplets as a metabolic vulnerability in melanoma by linking the pigmented cell state to increased fatty acid uptake and oxidative metabolism.

This study assesses the risks of China's overseas coastal development projects on marine biodiversity and Indigenous communities, identifying high-risk sectors and regions.

This study shows G6PD inhibition increases oxidative stress and reduces omental metastases in ovarian cancer.

The paper identifies a C-terminal glutamine recognition mechanism by TRIM7 that targets viral proteins, revealing its role in antiviral defense against norovirus and SARS-CoV-2.