Y. Ma

This study develops DNA origami nanomedicine to scavenge ROS and NO in M1 macrophages, converting them to M2 subtype and reducing RA inflammation in mice.

This study shows that male mice lacking the pituitary kisspeptin receptor have normal reproductive function despite increased basal FSH levels.

This paper identifies that a P4 N-terminal carbamate in boceprevir-based inhibitors is crucial for high antiviral potency against SARS-CoV-2.

This study identifies O-tert-butyl-threonine at the P3 site as critical for enhancing cellular and antiviral potency of MPro inhibitors.

The paper digitally reconstructs pectoral girdles of two Early Cretaceous birds, revealing morphological features and their implications for early flight evolution.

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

The paper applies deep learning to identify anther dehiscence states in cotton to screen for heat-tolerant varieties and support genetic breeding research.

This study shows that nucleobase clustering in RNA with repeat expansions leads to the formation and hollowing of RNA condensates, contributing to neurodegenerative disease mechanisms.

The paper investigates the genetic regulation of cannabinoid biosynthesis during female flower development in Cannabis sativa, identifying key enzymatic steps and gene regulation patterns.

The paper introduces an AuSERP biochip to detect single extracellular vesicle RNA and protein biomarkers for predicting immunotherapy responses in NSCLC patients, showing higher sensitivity than traditional methods.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study shows that type IV pili in bacterial consortia reduce spatial intermixing, forming a bubble-jet pattern that affects community productivity.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

This study identifies SLIT2 as a regulator of metastasis through a genome-wide CRISPR screen of circulating tumor cells in a mouse model.

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

This paper develops optimal dynamic incentive schedules for Hawk-Dove evolutionary games to maximize or minimize aggressive population frequency over time.

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

This study shows that aging stem cells accumulate labile iron, disrupting a key regulatory pathway that maintains their identity and function.

The paper identifies natural interploidy hybridization among wild chrysanthemum species involved in the origin of cultivated chrysanthemums, revealing patterns influenced by reproductive isolation and human activity.

This study determines the crystal structures of taxane-tubulin complexes and uses simulations to elucidate how taxanes stabilize microtubules through conformational changes and ligand binding.

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

The paper evaluates MPro inhibitors for SARS-CoV-2, finding MPI8 selectively inhibits both MPro and host cathepsin L, enhancing antiviral efficacy with reduced toxicity.

This paper evaluates the cellular potency of SARS-CoV-2 MPro inhibitors using a fluorescent flow cytometry assay, revealing that most inhibitors have weak cellular activity despite strong antiviral effects.

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

This study examines immune cell profiles in COVID-19 survivors with and without pulmonary sequelae one year post-discharge, identifying immune imbalances linked to residual lung damage.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

This study identifies PGAP1 as essential for GPI anchor lipid remodeling and transport of GPI-anchored proteins to the cell surface in Arabidopsis.

This study analyzes oral and gut viromes in RA patients and controls to explore their potential role in RA development.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.