Y. Xiong

The paper develops and simulates fully glycosylated ACE2-Fc fusion proteins and their interaction with SARS-CoV-2 spike protein RBD, showing glycan effects on conformation and optimizing glycosylation modeling algorithms.

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

The paper identifies a novel bacterial guanine nucleotide exchange factor (GEF) in Orientia tsutsugamushi that activates Rac1 and alters cell morphology.

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

This study identifies HAND2-AS1 as a tumor suppressor in cervical cancer by regulating miR-21 and ALEX1 to inhibit proliferation and EMT.

This study characterizes an obese ZSF1 rat model of cardiometabolic syndrome and shows that GDF15 treatment reduces metabolic markers and improves cardiac function.

The paper generates proteomic signatures of kinase inhibitor-induced cardiotoxicity using high-throughput proteomics and integrates them with transcriptomic data to predict drug toxicity.

This study shows that prior radiation therapy promotes tumor aggressiveness in glioblastoma by inducing metabolic changes that create a protumorigenic microenvironment.

This paper introduces a DNA-brick assisted centrifugation method to sort liposomes by size, enabling the study of membrane curvature effects on protein activity.

This study shows HIV-1 Vpr suppresses IRF7 and IFN-I expression in pDCs by degrading TET2, thereby enhancing HIV-1 replication.

This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.

The paper assesses the frequency of deleterious mutations in 21 hereditary breast and ovarian cancer genes among 882 high-risk Chinese individuals, finding 19.5% carried such mutations, with higher rates in those with both breast and ovarian cancer histories.

This study evaluates how golden apple snail residues affect soil properties and bacterial communities, finding that they increase soil nutrients and alter bacterial diversity and composition.

This study shows that primary endothelial cilia regulate islet vascularization and vascular barrier function through VEGF-A/VEGFR2 signaling, with impaired vascularization observed in Bbs4-/- mice.

This paper identifies an acidic cluster motif in SERINC5 that mediates resistance to HIV-1 Nef antagonism, showing its importance in Nef sensitivity without affecting intrinsic antiviral activity.

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

This paper identifies the molecular mechanism by which MxB restricts HIV-1 by binding to the tri-hexamer interface of the viral capsid.

This study shows Munc18-1 facilitates SNARE assembly by forming a template complex, and similar mechanisms are used by other SM proteins.

This study quantitatively analyzes amino acid sequence variability in HBV proteins to identify conserved and variable regions critical for virus assembly and immune recognition.

The paper identifies YrlA RNAs as tRNA mimics in bacteria, showing structural similarities to tRNAs but with key differences.

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.

The paper identifies that phosphoserine acidic cluster motifs in transmembrane proteins bind distinct basic regions on clathrin adaptor protein μ subunits, revealing potential for virus-specific inhibition.

This study shows that SAMHD1 suppresses HIV-1 gene expression and reactivation in CD4+ T-cells by binding to the HIV-1 LTR and inhibiting transcription.

This study compares monomeric and dimeric forms of FAN1, showing that dimerization is required for efficient cleavage of long DNA flaps.

This study investigates how APOBEC3G selects DNA substrates through structural, biochemical, and functional analyses, revealing key interactions and mechanisms involved in its antiviral activity against HIV-1.

This study determines the first crystal structure of full-length mouse SAMHD1 in three nucleotide-bound states, revealing a more complex activation process involving the SAM domain compared to human SAMHD1.