Y. Yan

This study identifies key molecular factors determining mosquito-borne flavivirus host tropism by comparing insect-specific and dual-host flaviviruses.

The paper shows that NOTCH1 variation within microtumors enhances invasiveness, linking intratumoral heterogeneity to collective cancer invasion.

This study investigates how ionic strength affects HU protein-induced DNA supercoiling and compaction using single-molecule techniques.

This study examines how nutrient enrichment and herbivory by an invasive snail interactively affect growth of an invasive macrophyte and native macrophytes in freshwater mesocosms.

This study proposes a co-sparse analysis model for registering intra-operative photoacoustic images with pre-operative MR images to improve brain shift compensation in neurosurgery.

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

The paper presents a Cryo-EM structure of the PP1c/PPP1R15A/G-actin complex that terminates the Integrated Stress Response by positioning eIF2's phosphoserine-51 at the active site.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study identifies MARCH1 and MARCH8 as specialized regulators of CD4+ T cell immunity in distinct cellular compartments by analyzing their substrates and expression in mice.

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.

The paper shows that positive supercoiling helps RNA polymerase bypass LacI-mediated DNA loops in E. coli by reducing pauses and enhancing dissociation of roadblocks.

The paper shows that negative DNA supercoiling reduces stochasticity in protein-mediated DNA looping, making it deterministic and ergodic within bacterial doubling time.

This study shows that the intrinsic movement order of voltage-sensing domains in Nav channels determines their susceptibility to regulation by β1 and β3 subunits, explaining variable regulatory effects across channel isoforms.

This study evaluates the impact of different sterilization methods on the properties of a conjugated polymer-based bioelectronic patch, finding that ethylene oxide and low-dose gamma irradiation best preserve its performance and minimize immune response.

This study identifies GajA as a nucleotide-regulated endonuclease from the Gabija bacterial defense system, which is inhibited by NTP and dNTP but activated during phage infection.

This study evaluates the effects of chronic bioelectric nerve stimulation on neuroskeletal health in diabetic rats, finding it does not prevent neuropathy or musculoskeletal complications but affects bone density and gait.

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

This study shows that calcium depletion affects BiP-substrate interactions by altering ADP affinity, impacting ER proteostasis and UPR activation.

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

This study identifies an epigenetic vulnerability in PI3K/AKT inhibitor-resistant cancers, showing that targeting bromodomain or HDAC inhibitors can overcome resistance by modulating histone acetylation at growth factor/receptor gene loci.

The paper examines the genomic bases of ecological diversification in core landbirds, identifying adaptive enhancements in diet and vision related to their lifestyles.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study investigates the molecular mechanisms of 2019-nCoV binding to human ACE2 and its evolutionary advantages over SARS-CoV using computational methods.