C. Chen

This study demonstrates a T4 phage-based vaccine platform that incorporates M2e antigens, showing high immunogenicity and complete protection against influenza without adjuvants.

This paper designs stabilized SARS-CoV-2 RBD variants using deep mutational scanning and structure-based design, showing improved thermal stability and manufacturability for vaccine applications.

This paper develops a protein-based gel that delivers Atsttrin to prevent post-traumatic osteoarthritis in a rabbit model.

This study investigates how high temperatures affect meiosis in autotetraploid Arabidopsis thaliana, revealing that heat stress disrupts chromosome axis stability and meiotic recombination.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

This study shows that ribosomal protein (RP) deficiency affects gene expression through translational and transcriptional changes, with distinct impacts on cell growth, apoptosis, and development.

The paper predicts the effect of amino acid changes on SARS-CoV-2 spike protein binding to hACE2 using molecular dynamics and a neural network, achieving 82.2% classification accuracy and 0.69 correlation with experimental data.

The paper evaluates an antibody domain's ability to neutralize SARS-CoV-2 variants with mutations in the RBD, showing it neutralizes the triple mutation variant but not others.

This study examines how Brucella outer membrane proteins and mutants affect dendritic cell maturation and antigen presentation in mice, revealing their roles in immune evasion and pathogenesis.

This study shows that a CTLA-4 nanobody enhances immune responses in mice challenged with Staphylococcus aureus and Streptococcus agalactiae.

The paper identifies a temperature-specific regulatory mechanism where Sty1 inhibits Orb6 kinase to enhance heat stress resilience and metabolic adaptation.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study shows that CpG-adjuvanted S-2P vaccine protected hamsters from SARS-CoV-2 infection by inducing high neutralizing antibodies and reducing viral load.

This study develops a next-generation sequencing-based sterility test (NGSST) that reduces detection time to 48 hours and improves accuracy for biological products.

This study investigates the existence and characteristics of the myodural bridge in Gentoo penguins, finding it analogous to humans but with unique features.

This study examines the evolutionary patterns of a Hawaiian spider and its microbial associates across volcanic islands, finding distinct diversification trends among host spiders, endosymbionts, and gut microbiota.

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

This study identifies a new orthonairovirus, SGLV, associated with human febrile illness in northeastern China, showing its presence in ticks and clinical symptoms in infected patients.

This study investigates the antibacterial activity of a plant lipase, PLIP1, against gram-negative bacteria and explores its potential as a novel antimicrobial agent.

GenOrigin systematically dates the age of 9.1 million protein-coding genes across 565 species and provides a database for gene age estimates and functional annotations.

This study shows heat stress inhibits meiotic recombination in Arabidopsis by reducing DSB formation and homolog synapsis, affecting chromosome axis stability and recombinase levels.

High school students benchmarked ensemble docking methods for ligand affinity prediction in a drug discovery challenge, finding Cathepsin S challenging and exploring advanced techniques.

This study evaluates phage-based FMDV vaccines through meta-analysis and experiment, showing protective effects and immune responses in mice.

The paper investigates the genomic basis of symbiosis in a vent snail, revealing a tripartite holobiont system involving host, endosymbionts, and gut microbiota, highlighting metabolic flexibility and mutualistic interactions.

This study shows that miR-200 deficiency in lung cancer cells promotes metastasis by activating cancer-associated fibroblasts through Notch signaling.

This paper develops a subunit vaccine against COVID-19 using CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen and shows it induces high neutralizing antibody titers and Th1 response in mice.