C. Chen

The paper aligns 2D histology images of AD pathology with 3D MRI to reconstruct NFT density in the MTL, finding high NFT density in the rostral hippocampus and adjacent regions.

The paper identifies CD274-expressing cells in human lungs that are expanded in IPF and show progenitor-like behavior in ex vivo assays.

A comparative transcriptome and DNA methylome analysis of inflorescence between upland and lowland ecotypes reveals gene expression and DNA methylation variation underlying inflorescence divergence in Panicum hallii.

This study shows that a two-dose intramuscular vaccine followed by an intranasal booster provides strong protection against SARS-CoV-2 in hamsters, reducing viral load and disease symptoms.

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

This paper investigates the CD46 receptor utilization by Ad26 in vitro and in vivo, showing its role in infection and safety, but not all routes of administration.

The paper evaluates FK1706, a non-immunosuppressive FKBP ligand, in vitro against SARS-CoV-2 alone and in combination with remdesivir, showing synergistic activity.

This study creates ECM models with varied topology, composition, and stiffness to study their impact on cellular phenotypes, showing EMT shifts are multidimensional and not solely dependent on single ECM features.

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

This study shows that air pollution particles promote lung cancer by hijacking peroxidasin to alter collagen crosslinking, impairing immune surveillance.

This study surveys veterinarians to assess cannabis-induced toxicosis in pets, finding increased cases post-legalization with mostly complete recovery but some fatalities.

The paper identifies genetic factors associated with endophytism in Arabidopsis root fungi, showing specific gene families linked to aggressive colonization and plant health.

This paper develops a microfabricated invasion assay for ovarian cancer spheroids to study tumor invasion and drug response.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study shows that TNF-α-stimulated BMSCs reduce oxidative stress and tissue damage in fatty liver IRI in rats.

This study develops a tetravalent antibody format that neutralizes SARS-CoV-2 variants with high potency and breadth, surpassing conventional bivalent antibodies.

This paper designs chiral nematic liquid crystal droplets as micro-sensors for detecting biological amphiphiles, showing unique optical responses and in vivo biosensing in zebrafish.

This study evaluates the efficacy of a vaccine regimen using wildtype and Beta variant S-2P in hamsters against SARS-CoV-2 Delta and VoCs, showing improved neutralization and protection with a mixed-dose schedule.

The paper shows p53 forms a nuclear PI3K-Akt pathway that activates Akt independently of the canonical membrane pathway, with implications for cancer therapy.

This study examines reproduction in deep-sea vent shrimps, finding that egg production varies with diet and phylogeny, and reproductive rhythms are not linked to surface production cycles.

This study shows that senescence promotes reprogramming through the SASP factor Amphiregulin, which enhances proliferation and MET via EGFR signaling, improving reprogramming efficiency.

This study sequenced Paspalum vaginatum, a stress-tolerant wild relative of maize, and found that inducing trehalose accumulation in maize increases biomass through autophagy.

This study identifies shared and unique cellular responses to moderate and acute high temperatures in Chlamydomonas reinhardtii, revealing mechanisms for thermotolerance.

This study shows that Bub1-mediated BubR1 recruitment to kinetochores enhances SAC signaling and reveals BubR1's dual role in SAC activation and silencing.

This paper develops an adaptive optics three-photon microscope for high-resolution imaging in deep brain tissue, achieving near-diffraction-limited performance and enabling functional calcium imaging and microsurgery through the intact skull.

This paper identifies the tetrameric assembly of AmnC as essential for NAD+ binding and enzymatic activity in 2-aminophenol metabolism.

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

The paper shows that SARS-CoV-2 exhibits substantial within-host genetic diversity, challenging the assumption of low diversity per infected individual and highlighting the importance of studying evolution within hosts.