C. Li

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

This study links spectral and genomic variation in European beech to support scalable monitoring of genetic diversity loss.

This study investigates the co-evolution of feeding organs in early elephantiforms, finding that feeding function shifted from the mandible to the trunk, enabling proboscideans to expand into new ecological niches.

This study identifies NUP1's role in Arabidopsis seed germination by mediating proteasome-dependent degradation of ABI5.

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

This paper identifies the molecular mechanisms of baculovirus-induced chromatin marginalization and structural changes, revealing the role of Lamin A/C-HP1a-H3K9me3 interactions and nuclear F-actin.

This study shows that GIGANTEA accelerates wheat heading time by interacting with genes in the flowering pathway, with effects dependent on photoperiod and vernalization.

This study shows that maternal undernutrition during pregnancy alters the molecular response to overnutrition in juvenile offspring, increasing risk of metabolic diseases.

This study constructs a multi-omic atlas of TP53-mutant lung adenocarcinoma tumors, revealing altered cellular identity, gene expression programs, and spatial interactions in the tumor microenvironment.

This study shows that SRSF2 mutations disrupt mitochondrial mRNA splicing, impair complex I function, and increase mitophagy through a PINK1 splicing mechanism, identifying mitophagy as a therapeutic target in MDS and AML.

This study shows that SWI/SNF chromatin remodeling is required for BZR1-mediated transcriptional activation in Arabidopsis thaliana.

This paper uses high-speed video and 3D modeling to analyze the jumping and landing mechanics of spotted lanternfly nymphs, showing they control orientation via posture and drag torques for successful landings.

This paper introduces a liquid-liquid interface system to model in vivo neutrophil migration, finding that neutrophils use bleb-based force generation to deform barriers under confining pressures.

The paper identifies lysinoalanine (Lal) crosslinks in spirochete flagellar hooks across multiple species, showing they are conserved and necessary for motility.

RBD-62, a high-affinity ACE2 antagonist, limits SARS-CoV-2 replication in both upper and lower airways in rhesus macaques without blocking memory responses or causing anti-drug immunity.

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

This study identifies CYP94C1 as a key enzyme in tomato that terminates jasmonate signaling during ripening by converting bioactive JA-Ile to an inactive form, thereby reducing susceptibility to necrotrophic pathogens.

This study shows that thrombocytopenia causes monocyte immune dysfunction through platelet-monocyte CD47 interactions, leading to increased TLR responses and altered immunometabolism.

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

The paper generates a high-confidence binary protein interaction network for Drosophila using yeast two-hybrid screens and integrates it with existing data to create a comprehensive reference network.

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

The paper uses proteomics and phosphoproteomics to analyze PPP2R5D variants, finding RPS6 hyperphosphorylation and mTORC1 activation through different pathways in E198K and E420K variants.