G. Wang

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study compares salt tolerance mechanisms in two extremophytes, showing they use distinct pathways to achieve similar adaptive traits.

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

This study acquires and analyzes the macromolecular MR spectrum in healthy adults across ages 20-69, finding no significant age or sex-related changes in macromolecule signals.

This study identifies key traits enabling Schrenkiella parvula to maintain growth and reproductive success under salt stress.

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

This study identifies adaptive features of the desert plant Anastatica hierochuntica by comparing its transcriptome to Arabidopsis thaliana under heat stress, revealing gene selection and expression patterns linked to heat tolerance and desert adaptation.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

This study analyzes ACE2 gene conservation and expression patterns in 11 animals, finding high conservation but species-specific RNA and protein expression.

This paper introduces a bifocal parallax single particle tracking method to study 3D rotational and translational motion of cargo in living cells, revealing new interactions at microtubule intersections.

This paper uses Maxent modeling to predict the global distribution of talaromycosis, identifying key environmental and epidemiological drivers.

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

The paper presents the cryo-EM structure of Drosophila GNPTAB, revealing its catalytic domain and functional residues, and shows dimer interface importance for human GNPTAB activity.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study compares the immunogenicity of spike proteins from Alpha- and Beta-coronaviruses, finding that Beta-CoVs induce stronger neutralizing antibodies against RBD than Alpha-CoVs.

This study analyzes oral and gut viromes in RA patients and controls to explore their potential role in RA development.

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.

The paper develops patient-derived xenografts and organoids for breast cancer to enable drug screening and precision oncology, showing efficacy of an FDA-approved drug in a clinical case.

This study shows Talaromyces marneffei induces M2 macrophage polarization by downregulating SOCS3 and activating TLR9, enhancing fungal survival.

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.

This study compares three qRT-PCR assays for SARS-CoV-2 detection, finding that CCDC and IPBCAMS N gene assays outperformed WHO assays, while IPBCAMS ORF 1b assay had higher detection rates than others.

This study identifies RIPLET as a ubiquitin ligase that activates RIG-I signaling and modulates innate immune responses to SARS-CoV-2 by polyubiquitinating RIG-I and LGP2.

This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.

This study identifies a bacterial bile acid metabolite, isoalloLCA, that enhances Treg cell differentiation via NR4A1 and is reduced in inflammatory bowel disease patients.

This study shows that GNS561, an autophagy inhibitor, effectively targets both cancer stem cells and bulk tumor cells in hepatocellular carcinoma and colorectal cancer metastasis.

This study shows extracellular histones stimulate collagen production in liver fibrosis via TLR4-MyD88 signaling, and NAHP reduces fibrosis by neutralizing histones.

This study maps the spatial organization of RNA in individual neurons using MERFISH, revealing distinct transcriptome compositions and sub-dendritic RNA distribution patterns.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.