G. Wang

This study creates a spatiotemporal transcriptome atlas of Schrenkiella parvula, revealing gene expression networks and responses to salt stress across developmental stages and tissues.

This study uses graph theory to analyze how temperature-dependent noncovalent interactions in aldolase B and its A149P mutant form a grid-like network that regulates structural thermostability and functional thermoactivity.

The paper identifies ICL-1 as a protein that protects against mitochondrial superoxide stress by activating the mitochondrial unfolded protein response.

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

This study identifies multiple factors influencing mitogenomic evolutionary rates in flatworms, with parasitism having the greatest impact despite its monophyletic origin.

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

The paper identifies novel viroid-like circular RNAs in a fungal host, showing they replicate autonomously and modulate host biology, suggesting a new class of viroid-like entities in fungi.

This paper identifies Marinifilaceae bacteria as key players in deep-sea organic matter mineralization, revealing their metabolic versatility and role in carbon and nitrogen cycling.

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

The paper compares antibody responses to different SARS-CoV-2 variants after vaccination and infection, finding that post-vaccination Omicron infection induces broader immunity than triple vaccination alone.

This paper identifies the biosynthetic pathway for lasonolide A in a marine sponge-associated bacterium using genome-resolved metagenomics.

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

This study constructs a spatiotemporal MRI atlas of fetal brain development in Chinese fetuses, revealing a central-to-peripheral cortical growth gradient and dynamic structural asymmetry.

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

This study quantifies neoantigen-mediated immunoediting stages in cancer evolution across tumor types, showing elimination and escape signals predict immunotherapy response.

This study identifies a Delta-Omicron recombinant SARS-CoV-2 variant that escapes Sotrovimab neutralization, highlighting the role of recombination in immune escape.

The paper uses single-cell multi-omic analysis to study TP53-mutant cancer evolution in leukaemia, identifying a role for chronic inflammation in promoting TP53 mutant clones.

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

This paper develops human bone marrow organoids to model hematological malignancies and validate therapeutic targets.

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

This study shows that extrachromosomal DNA (ecDNA) is linked to reduced immune cell infiltration and antigen presentation, suggesting it helps cancer cells evade immune surveillance.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

The paper uses graph theory to model temperature-dependent non-covalent interactions in TRPV1, showing how grid-like networks maintain its structure and govern heat-sensing.

This study uses a grid thermodynamic model to show that PIP2-dependent thermorings in TRPM8 are crucial for cold sensing through structured temperature-dependent interactions.

A third dose of Pfizer/BioNTech vaccine significantly boosts Omicron neutralizing antibodies, while convalescent sera and therapeutic antibodies show variable and often low neutralization.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study tracks immune cell changes in early systemic lupus erythematosus using mass cytometry and identifies longitudinal shifts in Tfh cells and CXCL10.