H. Chen

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

This study establishes a comprehensive FcγR reporter cell assay to detect and quantify soluble immune complexes in experimental and clinical settings.

This study evaluates the cardiac effects of azithromycin and hydroxychloroquine plus azithromycin in guinea pigs, finding QT interval prolongation and cardiac dysfunction with both treatments.

This study investigates the role of WRKY31 and signaling compounds in enhancing insect resistance in Pinus massoniana L. against Dendrolimus punctatus by modulating hormone signaling pathways.

The paper identifies a peroxidase inhibitor, 6D1, that enhances kanamycin activity against carbapenem-resistant bacteria.

This study identifies KIM1 as a potential receptor for SARS-CoV-2 in the kidney, showing it binds RBD with similar affinity to ACE2 and facilitates viral entry.

TailTimer automates the rodent tail immersion assay by recording tail withdrawal latency and water temperature, improving reproducibility and detecting genetic differences in thermal pain sensitivity.

This study shows that a Mediterranean diet improves stress resilience and delays age-related stress responses in nonhuman primates.

This study shows that C. elegans uses mitochondrial surveillance systems and the AMPK pathway to trigger innate immune responses against bacterial pathogens through non-PRR patterns.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This paper demonstrates a deployable DNA flight ring that switches between open and closed states, showcasing auxetic reconfiguration with negative Poissons ratios.

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

This study identifies enhancer subtypes in colorectal cancer through epigenomic analysis and proposes targeted therapeutic strategies based on these subtypes.

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

This study shows that hyperpolyploidization of hepatocytes in the centrilobular region initiates preneoplastic lesion formation, with AURKB upregulation and phosphorylation driving this process in HCC development.

This study examines the temporal metabolic and transcriptomic changes in islets and liver of mice on high-fat diet, revealing dynamic pathophysiology and interorgan crosstalk in diabetes.

This study designs auxetic two-dimensional DNA nanostructures using origami and shows that their properties depend on geometry and materials chemistry.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study investigates the mechanism of crosslinked 2-hydroxypropyl-β-cyclodextrin (HPβCD) in treating Niemann-Pick Disease Type C and evaluates its in vivo efficacy with MRIg-FUS to enhance brain penetration.

The paper uses single-cell RNA sequencing to identify early transcriptional changes in kidney cells after podocyte injury, revealing disrupted cell-cell interactions that contribute to chronic kidney disease progression.

The paper examines how PD-L1 expression on tumor cells affects specific cell clusters in TCR-T cells through single-cell RNA sequencing and cytotoxicity assays.

This study uses 3D printing to create vessel architectures that induce more physiologically relevant phenotypes in vascular smooth muscle cells compared to 2D cultures.

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

This paper evaluates a randomized basket trial design that controls false positive rate by indication, showing improved efficiency compared to parallel studies.

This study investigates how structural and dynamic features of the N-terminal domains of connexin 46 and 50 influence gap junction channel stability and conductance through molecular dynamics simulations and electrophysiology.

This study identifies METTL4 as the methyltransferase responsible for m6A methylation of U2 snRNA in Drosophila, confirming its enzymatic activity in vitro and in vivo.