H. Hu

This study shows that oral administration of BefA from E. coli reduces blood glucose and improves beta cell function in both T1DM and T2DM mice.

Mutations in the auxin importer gene Spp1/SvAUX1 reveal broad developmental effects in shoots, inflorescences, and flowers, with non-redundant roles among AUX1 homologs.

This study maps haplotype variation at the cqProt-003 locus in soybean, identifying structural variants and tandem repeats associated with high protein content and tracing their distribution across wild, landrace, and cultivated populations.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

The paper examines how selection for seed size in oats has influenced the abundance of specialized metabolites, finding uneven effects on different metabolite classes.

This study evaluates methods for creating gastrojejunostomy using magnetic compression and pyloric ligation in rabbits, finding that pyloric ligation provides better long-term patency than paclitaxel-loaded magnets.

The paper shows that CD4-targeted bacteriophage T4 nanoparticles reactivate HIV-1 latency in CD4+ T-cells without global activation or cytokine storm.

This study examines how nitrification inhibitors and straw incorporation affect N2O emissions and microbial communities in different cropland soils, finding that their effects vary by soil type.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports the origin of eukaryotes within Archaea.

The paper develops three RORγt inhibitors that reduce Th17 differentiation and inflammation in vivo and inhibit tumor growth in PDAC organoids.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

The paper identifies peptide ancestry informative markers (pAIMs) that correlate with ancestry in uterine neoplasms, showing they can accurately determine ancestry proportions with high precision.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

This study investigates how light intensity affects the coloration and structure of chimeric leaves in Ananas comosus var. bracteatus, finding that 50% shade optimizes growth and ornamental value.

This study shows that LRRC26-associated BK channels in goblet cells protect mice from colitis by regulating potassium flux and MUC2 secretion.

The paper examines mRNA expression patterns across nine species to assess the applicability of Haeckel's postulates, finding partial conservation and alignment with terminal edition patterns.

This study develops a simplified method to induce RPE-like cells from human fibroblasts and validates their properties using single-cell RNA sequencing.

The paper shows that methylation of Aub by piRNA loading is essential for piRNA amplification and transposon silencing in Drosophila.

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

The paper traces the evolution of sex determination in northern pike, revealing an ancient origin of the master sex-determining gene and recent transitions including Y-chromosome loss.

This paper identifies novel endocannabinoid epoxides that modulate TRPV1 and cannabinoid receptors, reducing inflammation and offering potential for new therapeutics.

This study uses scRNA-seq to analyze 110,745 cells from osteosarcoma tissues, identifying malignant subpopulations and TME components, and shows TIGIT inhibition enhances T-cell cytotoxicity.

This paper reanalyzes CT scan data of Oculudentavis and concludes it is a squamate, not a bird or archosaur, based on morphological evidence.

Knockout of 4CL1 in Populus reveals a 4CL5-dependent compensatory pathway for lignification with links to thiol redox balance and sulfur assimilation.

This study shows that Arabidopsis PPC2 is essential for growth at low CO2 by linking photorespiratory metabolism with primary metabolism and ABA signaling.

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.