H. Wu

This study investigates NTS1 allostery and signaling bias using NMR, showing PIP2 enhances transducer complexation through allosteric connections and β-arrestin modulates receptor conformation.

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

The paper uses molecular dynamics and AI to show eukaryotic histones can form stable homodimers, with disordered tails favoring heterotypic dimers.

This study investigates SMII filament dynamics in vascular smooth muscle cells, showing they are dynamic and stabilize during contraction, with implications for vascular regulation and disease.

The paper identifies and characterizes a novel hypovirus and its satellite-like dsRNA from Pestalotiopsis fici, showing it lacks a poly(A) tail and ORF, and negatively regulates the helper virus.

This study shows HDAC7 regulates CD8+ T cell function by controlling survival, calcium homeostasis, and memory responses, impacting anti-viral and anti-tumor immunity in mice.

This study identifies sialidases and fucosidases in Akkermansia muciniphila that degrade mucin glycans and enable nutrient sharing with gut bacteria.

This study optimizes primer sets for detecting Influenza A viruses using RRT-PCR, finding that HA primers are most sensitive for field sample detection.

This paper reports cryo-EM structures of the IgM BCR and its Fab-deleted form, revealing an asymmetric arrangement and novel structural principles of BCR assembly.

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study compares three transcytotic pathways for drug delivery to brain metastases of breast cancer and finds that albumin shows optimal distribution and uses a novel clathrin-independent endocytosis mechanism.

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

This study uses NMR and DFT to analyze sub-nanosecond motions of NTS1, showing ligands affect conformational entropy and dynamics.

This paper demonstrates baseline IMS resolution of intact isomeric proteoforms, specifically acetylated H4 histones, using trapped IMS on a Bruker TIMS/ToF platform.

This study identifies the thermodynamic state of aerobic glycolysis (TSAG) as a system property that stabilizes glycolytic flux in cancer cells, showing it resists perturbations and requires both enzyme inhibition and TSAG disruption for effective AG inhibition.

The paper uses CRISPR-based gene deletion to study Cre1's role in carbon catabolite repression in Coprinopsis cinerea, revealing its regulation of plant biomass degradation genes.

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

This study uses single-cell RNA sequencing to analyze shrimp hemocytes, revealing evolutionary parallels between invertebrate and vertebrate myeloid cells.

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

This study shows Piezo1 and 2 regulate centrosome integrity by modulating Ca2+ levels through mechanotransduction of cell intrinsic forces.

This study characterizes the kinetic and redox properties of KRASG12C inhibition, revealing pH-dependent covalent ligation and oxidation effects on protein conformation.

The paper builds a comprehensive Plant Virus Database (PVD) containing 3,206 virus species and 9,604 host interactions, revealing significant virome differences between plant groups and regions.

This study identifies Zfp281 as a regulator that inhibits the pluripotent-to-totipotent transition in mouse embryonic stem cells by repressing transcripts upregulated during the 2C-like state transition.

This paper shows a chemical molecule enhances the differentiation of biliary duct organoids into insulin-secreting cells, improving glucose sensitivity in diabetic mice.

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

This study uses spatial transcriptomics and single-cell RNA-seq to analyze immune microenvironment changes in gastric cancer progression, identifying immune cell dysregulation and key signaling pathways.

This paper introduces a novel Luminex-based immunoassay for multiplexed detection of EV surface proteins without requiring EV purification, demonstrating its ability to differentiate EVs from erythrocytes, macrophages, and neurons.

The paper uses genomic data to show that natural selection and demographic history jointly shaped the genetic structure and contact zones in Norway spruce during post-glacial recolonization.

The paper introduces NeoRdRp, a dataset of RNA-dependent RNA polymerase (RdRp) HMM profiles for identifying RNA viruses from metatranscriptomic data, showing improved detection compared to existing methods.