J. Feng

This study shows TRPM2 deficiency protects against atherosclerosis by inhibiting the TRPM2-CD36 inflammatory axis in macrophages, reducing plaque burden and inflammation.

This study shows that cyanophage PstS enhances host phosphate uptake and forms a chimeric ABC transporter with host proteins.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

This paper develops a qPCR protocol for detecting Xanthomonas translucens pv. undulosa in wheat, showing high specificity and sensitivity for bacterial detection.

This study determines the minimum number of Plasmodiophora brassicae resting spores required to infect canola, finding thresholds as low as 100 spores, lower than previously reported.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

The paper identifies Homo-harringtonine (HHT) as a potent antiviral drug against coronaviruses, effective in mouse models and safe in dogs, with potential for large-scale clinical use.

This study investigates how Trichostatin A (TSA) affects IL-17A-induced transformation of MRC5 cells into myofibroblasts and identifies the TGF-β1/Smads signaling pathway as the mechanism.

The paper isolates and characterizes cross-neutralizing antibodies from COVID-19 patients, identifying antibodies that neutralize both SARS-CoV-1 and SARS-CoV-2, including variants.

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

This study evaluates combination therapies of remdesivir and monoclonal antibodies for SARS-CoV-2 and its B.1.351 variant in mice, showing improved outcomes with the antibody combination.

This study compares the transcriptome responses of SARS-CoV and SARS-CoV-2 in human cell lines, finding broader but weaker host responses for SARS-CoV-2.

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

This study investigates how Alisertib affects KRAS mutations in colorectal cancer cells, showing allele-specific effects on RAS signaling and cell death mechanisms.

This study identifies the role of forehead gland secretions in conflict resolution among male Great Himalayan leaf-nosed bats through chemical analysis and behavioral experiments.

This study shows that human lung organoids can model SARS-CoV-2 infection and drug response, revealing virus targets and effective antiviral treatment.

This study shows hESCs-derived lung organoids can reconstruct human airway epithelium in vivo, with CD47high cells enhancing ciliated cell generation and epithelial thickness.

This paper develops a numerical model to simulate bleb formation and evolution in cells, showing how parameters affect bleb size and shape.

The paper determines the X-ray crystal structure of a potent SARS-CoV-2 neutralizing antibody, CV30, in complex with the RBD, showing its epitope overlaps with ACE2 binding site.

This study uses molecular dynamics simulations to describe the complete substrate exchange cycle of the antiporter NarK, revealing how paired basic residues facilitate substrate exchange.

This study characterizes neutralizing antibodies from a SARS-CoV-2 infected individual, finding that most antibodies are non-neutralizing and target epitopes outside the RBD, while two potent neutralizers bind the RBD with minimal mutation.

This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.

This paper develops microbial strains for producing renewable fatty acid esters, achieving high yields and economic competitiveness in bioproduction.

The paper develops and evaluates a LAMP assay for detecting ToBRFV, finding it efficient, rapid, and more sensitive than rt-PCR.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This paper characterizes two pectate lyases from Caldicellulosiruptor bescii, showing distinct degradation properties and roles of their CALG domain in plant biomass breakdown.

This paper introduces a BLSTM network to separate overlapping bat calls, achieving high separation quality and species classification accuracy.