L. Wang

This paper develops a compartmental model to deconvolve plasma pharmacokinetics from dynamic heart imaging data, enabling accurate analysis of radiotracer kinetics without invasive plasma sampling.

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

The paper identifies 70 novel genes involved in photosynthesis regulation and biogenesis using genetics in Chlamydomonas reinhardtii and characterizes their functions through mutant proteomics.

This study shows that Src and Hif1α activation increases glycolytic ATP production near endothelial adherens junctions, facilitating their re-assembly after injury.

The paper provides a comprehensive analysis of immune contexture in IDH stratified human gliomas using single-cell RNA sequencing and spectral cytometry, identifying TREM2 as a novel immunotherapy target.

This study shows that RNA polymerase collisions in E. coli regulate bidirectional transcription termination through head-on and co-directional interactions.

This study identifies distinct molecular mechanisms for proactive and retroactive interference in Drosophila during consecutive learning tasks.

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.

This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.

This study identifies activin A's role in bone fracture repair by promoting a novel myofibroblastic progenitor cell population that drives chondrogenesis and osteogenesis.

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

The paper identifies WSTF as a nuclear inhibitor of inflammation degraded by autophagy, showing its role in inflammation, cancer, and immune surveillance.

This study identifies TRAF6 as a regulator of PD-L1 expression in melanoma through YAP1-TFCP2 signaling, showing TRAF6 inhibition enhances anti-tumor immunity.

This study identifies a population of oxytocinergic sympathetic neurons that regulate adipose tissue lipolysis and metabolic homeostasis in mice and humans.

This study shows retrotransposons use the alt-EJ DNA repair pathway to generate eccDNA and achieve mobilization.

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

The paper constructs a golden section model of macroevolution integrating metabolic scaling and Fibonacci sequence to explain the origin and direction of the scaling exponent b in evolution.

This study uses supervised machine learning to identify microbial fingerprints in urban and oceanic environments, achieving high accuracy in location classification.

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.

This study shows that far-red light enhances maize's response to herbivore-induced volatiles by altering photosynthesis and phytochrome B signaling.

This study identifies Neu1 as a therapeutic target for coronavirus infection by showing its role in sialylation of viral proteins and demonstrates that a Neu1 inhibitor reduces viral replication in vitro and in vivo.

This paper develops a visual perception system using pose estimation to analyze fish swimming and provides code and dataset for the method.

The study identifies CsFLC1 in tea plants, showing it influences flowering and bud dormancy, and demonstrates its function in Arabidopsis by promoting early flowering and affecting gene expression related to flowering and hormone pathways.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

This paper identifies an antibody, WS6, from a mouse immunized with SARS-CoV-2 spike mRNA, which neutralizes diverse beta-coronaviruses by targeting a conserved helical epitope on the S2 subunit.

This study measures steric pressure generated by intrinsically disordered domains of AP180 at membrane surfaces, finding that they produce significant pressure through entropic and electrostatic mechanisms, independent of molecular weight.

This paper demonstrates the synergistic potential of niraparib and doxorubicin in ovarian cancer treatment and develops folate receptor-targeted nanoparticles for their delivery.

This study compares alignment-free k-mer hash and ASV methods for classifying fresh produce safety and quality using microbiome data, finding higher accuracy with k-mer hashes.