L. Zhao

This study shows that FYN tyrosine kinase in glioma cells suppresses anti-glioma immune responses, and its inhibition reduces tumor growth and improves survival in immune-competent models.

This study shows that choroidal macrophages maintain choroidal vasculature and RPE integrity, and their depletion leads to atrophy and structural changes, which can be reversed by regeneration.

This study identifies qKW9, a gene affecting maize kernel weight by regulating photosynthesis through C-to-U editing of NdhB.

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

The paper identifies and localizes subunits of the ciliary central apparatus using cryo-electron tomography and genetic approaches in Chlamydomonas.

The paper describes the establishment of hTERT-immortalized RPTE cells for studying BK polyomavirus infection.

The paper introduces a timescale-specific variance ratio metric to quantify compensatory dynamics in ecological communities and applies it to grassland data, showing variation in compensation across timescales.

This study uses single-cell RNA-seq to analyze de novo gene expression and mutational patterns in Drosophila testis across spermatogenesis.

This study uses single particle cryo-EM to determine the structure of 52 kDa streptavidin at 3.2 Angstrom resolution, demonstrating the feasibility of high-resolution imaging for small molecules.

This study evaluates the efficacy and adverse effects of antibiotics in treating M. abscessus pulmonary disease, finding that four antibiotics correlate with treatment success but are associated with severe side effects.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

This study investigates the nonreciprocal and conditional cooperativity between Sox2 and Oct4 in nucleosome targeting using single-molecule fluorescence microscopy.

This study shows that PIKfyve deficiency in myeloid cells impairs lysosomal function, leading to systemic inflammation and tissue infiltration in mice.

This study identifies the RhoA-myosin II axis as a mechanism enabling cancer cells to resist mechanical destruction by hemodynamic forces in circulation.

This study identifies the Kp citrate synthase gene gltA as critical for metabolic flexibility during infection, showing organ-specific fitness defects in lung and gut colonization.

This study compares bacterial composition and functional differences between cancerous and noncancerous ovarian tissues using 16S rRNA sequencing and metagenomic predictions.

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

This study identifies and characterizes a novel pic gene cluster in Alcaligenes faecalis JQ135 responsible for complete picolinic acid degradation into the tricarboxylic acid cycle.

The paper identifies HCSs associated with AT-less type I PKSs through genome mining and reveals their diversity across strains and soil samples.

This study identifies hemorrhagic myocarditis in mice induced by TLR-7 agonist using multi-parametric cardiac MRI, showing distinct T1, T2, and T2* relaxation patterns.

This study demonstrates that tungsten oxide nanodots exhibit strong antibacterial activity against both gram-negative and gram-positive bacteria, with enhanced efficacy under sunlight exposure and confirmed biocompatibility.

This study investigates whether BMP-2 promotes neovascularization directly or indirectly during bone regeneration and finds that it acts through paracrine signaling.

This paper shows that pre-existing host range mutations in RNA viruses restrict the genetic pathways available for further host range expansion, using bacteriophage phi6 as a model system.

The paper identifies structural and thermodynamic rules governing docking domain interactions in NRPSs, enabling predictable changes in peptide product spectra through residue exchange.

This study demonstrates that Nano-DOX-loaded TAM can reprogram GBM cells to an anti-GBM phenotype through DAMP emission, enhancing immune response and reducing tumor growth.

This paper identifies HpaM, a novel FAD-dependent monooxygenase in Alcaligenes faecalis JQ135, which catalyzes 2-decarboxylative hydroxylation of 5HPA to produce 2,5-DPH.

This study identifies Rab18 as a critical host factor for BKPyV infection through a whole-genome RNA interference screen in human renal cells.

The paper demonstrates the use of Volta phase plate with Cs-corrected TEM to achieve near-atomic resolution structures of apo-ferritin from over-focused images.