Q. Chen

This study shows that pre-activating γδT cells with IL-12/18/21 enhances their anti-tumor activity and overcomes resistance to anti-PD-L1 therapy in mouse models.

The paper investigates how the cytoplasmic tail of Pkd2 regulates its clustering in fission yeast eisosomes, showing that both plasma membrane microdomains and the cytoplasmic tail are involved.

This study engineers a SARS-CoV-2 spike protein with a disulfide bond to stabilize the locked conformation, revealing structural dynamics and the role of domain D in conformational changes and viral fitness.

This study models red blood cell dynamics in extravascular tissues as disordered porous media, finding that structural disorder increases apparent viscosity and promotes RBC homogeneity.

The paper profiles autoantibodies in peritoneal fluids of women with endometriosis, identifying significant autoantibody prevalence and associations with infertility and disease mechanisms.

This study develops Nm-VAQ, a qPCR-based method to precisely validate and quantify RNA 2'-O-methylation sites, demonstrating its application on rRNA.

This study maps lactylation sites in Toxoplasma gondii and identifies its role in gene regulation and metabolic processes.

This study shows that Pkd2, a putative ion channel in fission yeast, allows calcium influx when activated by membrane stretching during cytokinesis.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This study demonstrates the production of humanized IgG and IgM antibodies in plants for Valley Fever diagnostics, showing they maintain antigen recognition similar to FDA-approved kits.

This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.

This study shows that Flotillin-2 negatively regulates EGFR activation, ubiquitination, trafficking, and degradation, thereby suppressing cancer growth.

This study identifies tRNA thiolation as essential for plant immunity by showing its role in regulating NPR1 translation and salicylic acid signaling in Arabidopsis.

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

The paper shows the pre-B cell receptor changes Galectin-1's binding specificity from exo- to endo-type, promoting pre-B cell survival.

This study shows that sowing date affects temperature and light conditions during rice growth, which in turn modifies cadmium content in brown rice by regulating Cd-related gene expression.

This study examines how mutations in SARS-CoV-2 variants affect Spike-specific T cell responses, finding that some mutations reduce CD8 T cell recognition while overall T cell responses remain largely intact.

The paper determines the crystal structure of the Caskin1/CASK complex, revealing the molecular basis of CASK_CAMK domain binding specificity and identifying new potential binding partners.

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

This study investigates endothelial-immune interactions in NAFLD, showing increased chemokine expression and immune cell infiltration, and demonstrates that targeting the CXCL12-CXCR4 axis can restore endothelial barrier function.

This paper investigates the concordance between two methods for detecting positive selection and finds that they often disagree, suggesting negative selection variation may mislead positive selection inferences.

The paper uses patient-derived iPS cells to model liver pathologies in telomeropathies and identifies AKT suppression as a potential therapeutic target.

This paper investigates the impact of 14 non-synonymous SNPs in HIV on viral fitness, finding that specific mutations in integrase and RNase H impair GagPol autoprocessing and replication.

This study shows that S100A8 and S100A9 subunits inhibit HIV replication in macrophages but not T cells, despite their role in SARS-CoV-2 infection.

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

This study shows azacytidine limits SARS-CoV-2 infection and protects mice by disrupting viral RNA methylation.

This study compares inbreeding depression in maize and teosinte, finding greater depression in maize due to polygenic small-effect recessive variation and reduced large-effect variants after domestication.

The paper quantifies polymerized actin in fission yeast contractile rings and shows cofilin and type II myosins regulate actin dynamics during cytokinesis.

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

This paper presents a drug candidate, NANA-Me, that prevents and treats ADAA-based diseases caused by pathogenic anti-spike antibodies in COVID-19 and vaccines.