Q. Chen

This study identifies that ER-targeted mRNAs can be recruited into stress granules during the UPR and shows that transcriptional state influences SG formation.

This study investigates the antimicrobial synergy between ibuprofen and standard-of-care antibiotics against CF pathogens, showing in vitro and in vivo efficacy against drug-resistant strains.

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

The paper develops an automated classifier to detect Hainan gibbon calls using deep learning, achieving high accuracy and reducing manual processing time.

C010DS-Zn induces parthanatos in cancer cells, triggering anti-tumor immune responses involving T cells and macrophages in vivo.

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

This study compares long-term effects of grazing and mowing on plant diversity and community composition in salt marshes across spatial scales.

The paper identifies CDK12 inhibition as a strategy to enhance EGFR blockade efficacy in TNBC by targeting translation and stability of oncoproteins like MYC through 4E-BP1 and CCR4-NOT complex.

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

This paper integrates crop growth and radiative transfer models with deep learning to improve the estimation of crop traits from hyperspectral data.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

This paper introduces a rapid method for sample partitioning into microwells for digital bioassays, achieving high-density arrays with over 100,000 wells in under 30 seconds.

The paper identifies calcium spikes during fission yeast cytokinesis and shows they promote contractile ring constriction and daughter cell integrity.

The paper investigates the effects of YAP1/TAZ transcriptional inhibition in cancer cells, revealing TEAD-dependent and independent roles in tumor proliferation and differentiation.

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.

The paper identifies a novel dermal migratory Langerhans-like cell population using fate mapping and single-cell RNA sequencing, showing distinct migration and replenishment characteristics compared to Langerhans cells.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

The paper identifies two distinct sinoatrial nodes in mammalian hearts, sSAN and iSAN, which control fast and slow heart rates under sympathetic and parasympathetic stimulation, respectively.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

The paper identifies six amino acid substitutions associated with HCV treatment failure that are not resistance-associated substitutions but are highly represented in viral quasispecies.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This study shows SARS-CoV-2 infection causes temporary olfactory dysfunction in mice by targeting olfactory epithelium cells and disrupting their structure and function.

This study investigates TRPM2's role in pancreatic cancer, finding it promotes proliferation, migration, and invasion through the PKC/MAPK pathway.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study identifies altered small RNA modifications in Alzheimer's disease post-mortem samples compared to controls, with specific reductions in certain small RNA types.

This study shows that GSK3 inhibition improves growth and telomere function in DC patient-derived AT2 cells by enhancing Wnt signaling.

This study reevaluates Spinach-based RNA visualization in plants, showing potential for ex vivo and in vivo RNA monitoring.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.