Q. Liu

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

This study tests if chronic traffic noise affects parental behavior and reproduction in zebra finches, finding increased nest attendance but no impact on offspring outcomes.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

This paper develops a new mouse model of diffuse midline glioma to evaluate IL13R2-targeted immunotherapies, showing tumors with histopathological features of pediatric gliomas.

The paper tests if AlphaFold-predicted protein structures can be used for sequence-independent molecular replacement in crystallography, successfully determining two unknown contaminant structures.

This study uses additive textile manufacturing to create helically aligned cardiac muscle models, showing improved mechanical function compared to circumferential models.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.

This paper shows that PSGL-1 is incorporated into HIV-1 virions, reducing infectivity, but also facilitates trans-infection by binding P-selectin.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

This study introduces a new microscopy technique combining deep learning and light-sheet design to visualize organelle interactions in live cells with high spatial and temporal resolution.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study identifies ZmHXK7 as a maize hexokinase gene that improves salt tolerance in transgenic Arabidopsis by enhancing seedling growth and reducing stress inhibition.

This study identifies EXOSC1 as an endogenous source of mutation in KIRC that promotes DNA damage and sensitizes cells to PARP inhibitors.

This study shows that the Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes by modulating YAP/TAZ activity, with small molecules enhancing proliferation in low-density conditions.

This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

The paper uses multi-scale predictive modeling to identify ibudilast as a potential therapeutic for Alzheimer's disease by improving cognition and reducing pathology in a transgenic rat model.

This study shows that two rice pests, the brown planthopper and the rice striped stem borer, cooperate by jointly attacking rice plants, improving plant quality and reducing parasitism risk.

This study develops and evaluates two multi-epitope vaccines against H. pylori using computer-aided design, showing they reduce bacterial colonization and stomach damage in infected mice.

The paper determines the structure of the SARS-CoV-2 E protein-PALS1 complex using cryo-EM, revealing a hydrophobic interaction that explains viral spread and suggesting therapeutic targets.

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.

This study develops a multi-epitope chimeric antigen (MECU) that generates a broadly reactive antibody response against H. pylori and reduces stomach colonization in mice.

The paper identifies and evaluates strong constitutive promoters in Listeria monocytogenes to enhance foreign antigen expression, finding P18 as the most effective.

This study identifies CTPS1 as a target for antiviral therapy by showing it suppresses interferon induction and promotes viral replication in SARS-CoV-2 infection.

This study develops an OMV-based vaccine using Salmonella Typhimurium to deliver Shigella flexneri 2a O-polysaccharide antigen, showing protection against lethal pulmonary infection in mice.

This study shows that inhaled anesthetics reduce neural excitability by disrupting multiple-water entanglement networks, which amplify hydroxide ion concentration changes.

This study identifies a novel folliculogenesis and follicular placentation mechanism in black rockfish, highlighting hormonal changes and conserved genes in placental development.

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

This study links phospholipid and lysophospholipid levels to faster HIV rebound after treatment interruption, suggesting their role in viral persistence and inflammation.