S. Jiang

The paper introduces a database of non-covalent interactions in protein-ligand complexes using experimental electron density data and demonstrates its application in studying amide-pi interactions.

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

The paper identifies a conserved CTL epitope in the SARS-CoV-2 spike protein that is compatible with most HLA alleles and suitable for evaluating CD8+ T cell responses.

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

This study shows SARS-CoV-2 infects human adipose tissue, causing inflammation linked to severe COVID-19 outcomes in obese individuals.

This study shows KMT2D loss in HNSCC leads to enhancer reprogramming and immune microenvironment changes, promoting tumor growth through interferon signaling disruption.

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

The paper develops a method to track subclonal tumor patch behaviors using spatial epitope barcoding and imaging, revealing emergent properties in cancer cell states.

The paper investigates how gut microbiota respond to different prebiotics within individuals and links these responses to habitual fiber intake.

The paper shows the human gut microbiome retains a memory of past carbohydrate exposures, enhancing future metabolic responses through rapid transcriptional changes.

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

The paper develops PANINI-MIBI to analyze DNA, RNA, and protein in SIV-infected tissues, revealing IL10 upregulation and macrophage polarization linked to viral latency.

The paper depletes adult microglia using CSF1R inhibition and shows that subventricular zone/white matter myeloid cells dynamically repopulate the brain, exhibiting distinct phenotypes from endogenous microglia.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

The paper identifies and characterizes pro-growth enhancers in cancer cells using CRISPR screens, finding lineage-specific enhancers associated with poor prognosis and potential therapeutic targets.

The paper develops a cost-effective microscopy system for high-throughput optical recordings of visceral afferent activity in mouse dorsal root ganglia.

The paper analyzes damping time across 600+ species and finds it scales with generation time, independent of demographic dispersion, suggesting slow life-history species are more vulnerable to disturbances.

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

This paper introduces spatially expandable fiber-based probes for deep brain interface, enabling three-dimensional recording and stimulation of neural activity with high resolution and minimal tissue damage.

This study shows that the bacterial effector RipAC targets PUB4 to inhibit PTI by disrupting BIK1 homeostasis.

This study evaluates the impact of preoperative α-blocker use on outcomes in extra-adrenal retroperitoneal paraganglioma surgeries, finding no significant differences in postoperative complications.

This study shows that SARS-CoV-2 attached to salmon can remain infectious for over a week at 4°C, indicating a potential transmission risk in seafood markets.

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

This study identifies drug-tolerant persisters (DTPs) in HER2+ breast cancer and reveals their origins and vulnerabilities to TKI resistance.

The paper investigates the role of hydrophobin-enriched vesicles in mold sporulation, showing their intracellular accumulation and secretion contribute to spore hydrophobicity and rapid sporulation.

The paper identifies AMPK substrates and their roles in DNA damage response and histone acetylation through phosphoproteomics and histone modification analysis.