X. Li

The paper designs extendable protein multiplexes with symmetric architectures to create precisely patterned nanofibers through controlled repeat propagation and hydrophilic patch placement.

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

Deep network-based protein design generates symmetric homo-oligomers with high structural accuracy, demonstrating the potential for creating novel nanomachines and biomaterials.

This paper develops a novel mouse model of TNBC by combining MYC amplification and PTEN deletion, showing it recapitulates human TNBC heterogeneity through omic analyses.

The paper identifies WSTF as a nuclear inhibitor of inflammation degraded by autophagy, showing its role in inflammation, cancer, and immune surveillance.

This paper introduces a cryoFIB milling workflow for isolating objects of interest from large tissue samples, resulting in thin lamellae suitable for cryo-electron tomography.

This study compares water use strategies in soybean and cowpea under drought using phenomic and transcriptomic analyses, identifying gene networks and regulatory mechanisms underlying their contrasting responses.

The paper investigates sugarcane protoplast responses to enzymolysis using physiological, cytological, proteomic, and transcriptomic analyses, revealing changes in antioxidant activity, cell structure, and gene expression.

The paper develops a deep learning model that classifies metastatic tumors from primary tumors using mutational signatures from genomic data.

This study compares transcriptomic and metabolomic responses to drought in two switchgrass genotypes, identifying specialized diterpenoids as key to drought tolerance.

This study shows that loss of ANT1 increases fibrosis and epithelial cell senescence in IPF by causing mitochondrial dysfunction.

The paper presents a grasshopper genome assembly and finds conservation of X chromosome gene content across insect orders and evidence of recent evolutionary bursts in X-linked genes.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

This study shows that tumor removal increases prostate cancer cell dissemination to bones, while osteoblasts induce dormancy through focal adhesion kinase inhibition.

The paper establishes and characterizes a continuous Atlantic mackerel skeletal muscle cell line with myogenic and adipogenic-like phenotypes.

This paper introduces a method to locate cellular contents during cryoFIB milling using secondary-electron imaging, demonstrating its feasibility across different instruments and conditions.

This study characterizes viral diversity and host interactions in deep-sea hydrothermal vents, revealing novel viral lineages and metabolic roles in host adaptation.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

This paper evaluates downsampling methods for integrating fiber orientation into finite element models and finds that voxel-wise orientation implementation reduces errors in tract-related strain calculations.

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

This study identifies aCcr1, an RHH protein in Sulfolobales and their viruses, which regulates cell cycle progression by modulating gene expression related to division and replication.

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study simulates transmembrane potential and electroporation caused by time-varying magnetic fields, showing that nanosecond pulses are more effective than sub-microsecond pulses for membrane electroporation.

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

This study reports the cryo-EM structure of the NuA4 complex bound to a nucleosome, revealing its mechanism of nucleosome recognition and transcription coactivation.

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

The paper identifies transcriptional changes in endothelial cells due to environmental factors like shear stress and heterotypic interactions, showing their impact on gene expression independent of genetic background.

The paper investigates how rhizobia move through Medicago truncatula root cells by analyzing the role of SyPME and NPL in cell wall modifications during infection thread progression.

The paper identifies archaeal proteins homologous to eukaryotic gamete fusion proteins and shows they can mediate cell fusion.