X. Li

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

This paper reports the genome assembly of Vaccinium darrowii, identifies adaptation traits, and delineates cuticle biosynthesis pathways to aid blueberry breeding.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

This study identifies miR-144 as a regulator of adipogenesis by mediating the formation of the C/EBPα-FoxO1 protein complex, which influences AdipoQ expression and adipocyte differentiation.

The paper identifies RPG as required for infection thread formation in Lotus japonicus and shows it interacts with CERBERUS to mediate polarity growth driven by nuclear migration.

This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.

This paper develops photoswitchable nanovesicles (azosomes) for precise optical control of molecular release in neurons, demonstrating their ability to activate dopamine receptors in cultured striatal neurons.

This study identifies ATP12A as a potential therapeutic target for idiopathic pulmonary fibrosis by showing its overexpression in IPF lungs and its role in worsening fibrosis in mice.

This study demonstrates that optical modulation of the blood-brain-tumor barrier enhances drug delivery and suppresses tumor growth in glioblastoma models.

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

This study investigates how laser stimulation of endothelial-targeted nanoparticles increases blood-brain barrier permeability through calcium signaling and cytoskeletal changes.

The paper develops a red-shifted NanoLuc variant (QLuc) and uses it for in vivo immunobioluminescence imaging to improve deep-tissue visualization in mice.

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

This study constructs a comprehensive phylogenomic tree of butterflies and finds they originated in the Americas, diversified in the Paleotropics, and followed a 'cradle' pattern of dispersal.

This study shows Aspergillus tabacinus LZ-M can degrade acid red 73 anaerobically through a self-redox mechanism, mineralizing it to CO2 with a 90.28% decolorization rate in 5 days.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

This study shows that in C. elegans, D-2HG is produced via the propionate shunt and that loss of dhgd-1 causes embryonic lethality by disrupting ketone body metabolism, which can be rescued by vitamin B12 or 3-hydroxybutyrate.

This study characterizes fecal bacterial communities in dairy cattle across different management units, finding dynamic changes in diversity and composition.

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

Serum proteome profiling identifies subsets of long COVID patients with evidence of persistent inflammation and key immune signaling pathways.

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

This paper qualifies an improved multi-attribute method (MAM) for mAb identity, quality attributes, and new peak detection using Lys-C digestion and high-resolution MS.