X. Li

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

This study shows that an amino acid-enriched elemental diet reduces mucolytic bacteria and protects the mucus layer in mice with colitis.

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

This study identifies HAO2 as a regulator of fatty acid metabolism in CKD rat kidneys, showing its reduced expression and role in lipid accumulation and metabolic dysfunction.

This paper designs high-affinity protein binders for bioactive helical peptides using deep learning and generative models, achieving picomolar affinity without experimental optimization.

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

The study analyzes microbiome profiles across maternal-fetal tissues, revealing distinct microbial compositions and correlations based on anatomical position.

This paper introduces an Odourgenetic method using Drosophila odorant receptors to non-invasively and rapidly manipulate cellular functions and behavior through inhalation of 2-pentanone.

The paper uses simulations to show that cell size polydispersity and deformability explain the viscosity plateau in non-confluent zebrafish tissue beyond a critical packing fraction.

The paper shows that cell division and apoptosis in epithelial monolayers generate turbulent-like flows with energy spectra and velocity correlations similar to inertial turbulence.

The paper develops a stochastic model to explain dwell time distributions of actin and fimbrin during clathrin-mediated endocytosis in yeast, showing fast actin disassembly and mechanosensitive fimbrin detachment.

This study examines the toxicity of PCB mixtures on human adipose MSCs, finding two types of toxicity that impair growth and function.

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

This study shows lysosomes mediate the mitochondrial UPR through mTORC1-dependent ATF4 phosphorylation, essential for mitochondrial redox homeostasis and cell survival under stress.

This study shows that inhibiting Pyk2 reduces AIEC replication in macrophages and inflammatory cytokine release, suggesting a potential therapeutic target for Crohn's Disease.

This study identifies ESCRT-III homologs in magnetotactic bacteria, showing their role in membrane remodeling and multicellular morphogenesis through genomic and imaging analyses.

This study shows that AHR activation by dietary ligands improves gut barrier function via zinc-dependent pathways, highlighting the role of zinc in AHR signaling and its protective effects against IBD.

This paper introduces DeepSeMi, a self-supervised denoising framework that enhances fluorescence microscopy by increasing SNR and enabling long-term, high-resolution imaging of cellular processes.

This study identifies AdgB and AdgI as key proteins in the Variovorax auxin-degradation operon, revealing their roles in IAA uptake and conversion to oxIAA, and demonstrates the operon's potential for IAA regulation in E. coli.

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

The paper identifies multiple glutamine metabolism pathways in ccRCC tumorgrafts and shows that targeting amidotransferase activity reduces tumor growth.

This study identifies a polygenic mechanism on the Z chromosome causing hybrid incompatibility in butterflies, explaining Haldane's Rule and the large-X/Z effect through introgression skew and variability.

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

The paper shows mechanical force induces DRP1-dependent asymmetrical mitochondrial fission, leading to mtDNA-free fragments that recruit Parkin proteins.

The paper shows that some Topologically Associating Domains (TADs) persist without cohesin, supported by Hi-C data, polymer simulations, and 3D structural analysis in mouse and human cells.

The paper reports the structure of NTSR1 bound to GRK2, Gq, and a biased ligand, revealing how the ligand enhances GRK2 binding and enables arrestin-biased signaling.

This study shows FGFR1 promotes prostate cancer by enhancing iron metabolism through regulation of IRP2 post-translational modification and TFR1 expression.

This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.